Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Akt1s1 | Deptor | ENSRNOP00000027478 | ENSRNOP00000005722 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | DEP domain-containing MTOR-interacting protein. | 0.999 |
| Akt1s1 | Eif4ebp1 | ENSRNOP00000027478 | ENSRNOP00000016885 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Eukaryotic translation initiation factor 4E-binding protein 1; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase a [...] | 0.966 |
| Akt1s1 | Mapkap1 | ENSRNOP00000027478 | ENSRNOP00000023889 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...] | 0.966 |
| Akt1s1 | Mlst8 | ENSRNOP00000027478 | ENSRNOP00000014269 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.999 |
| Akt1s1 | Mtor | ENSRNOP00000027478 | ENSRNOP00000014167 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.999 |
| Akt1s1 | Rheb | ENSRNOP00000027478 | ENSRNOP00000063915 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. | 0.994 |
| Akt1s1 | Rictor | ENSRNOP00000027478 | ENSRNOP00000030782 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | RPTOR-independent companion of MTOR, complex 2. | 0.984 |
| Akt1s1 | Rps6kb1 | ENSRNOP00000027478 | ENSRNOP00000005226 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] | 0.985 |
| Akt1s1 | Rptor | ENSRNOP00000027478 | ENSRNOP00000005337 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Regulatory-associated protein of MTOR, complex 1. | 0.999 |
| Akt1s1 | Tti1 | ENSRNOP00000027478 | ENSRNOP00000017213 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Similar to KIAA0406-like protein (Predicted). | 0.977 |
| Deptor | Akt1s1 | ENSRNOP00000005722 | ENSRNOP00000027478 | DEP domain-containing MTOR-interacting protein. | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | 0.999 |
| Deptor | Eif4ebp1 | ENSRNOP00000005722 | ENSRNOP00000016885 | DEP domain-containing MTOR-interacting protein. | Eukaryotic translation initiation factor 4E-binding protein 1; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase a [...] | 0.550 |
| Deptor | Mapkap1 | ENSRNOP00000005722 | ENSRNOP00000023889 | DEP domain-containing MTOR-interacting protein. | Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...] | 0.998 |
| Deptor | Mlst8 | ENSRNOP00000005722 | ENSRNOP00000014269 | DEP domain-containing MTOR-interacting protein. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.999 |
| Deptor | Mtor | ENSRNOP00000005722 | ENSRNOP00000014167 | DEP domain-containing MTOR-interacting protein. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.999 |
| Deptor | Rheb | ENSRNOP00000005722 | ENSRNOP00000063915 | DEP domain-containing MTOR-interacting protein. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. | 0.987 |
| Deptor | Rictor | ENSRNOP00000005722 | ENSRNOP00000030782 | DEP domain-containing MTOR-interacting protein. | RPTOR-independent companion of MTOR, complex 2. | 0.999 |
| Deptor | Rps6kb1 | ENSRNOP00000005722 | ENSRNOP00000005226 | DEP domain-containing MTOR-interacting protein. | Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] | 0.974 |
| Deptor | Rptor | ENSRNOP00000005722 | ENSRNOP00000005337 | DEP domain-containing MTOR-interacting protein. | Regulatory-associated protein of MTOR, complex 1. | 0.999 |
| Deptor | Tti1 | ENSRNOP00000005722 | ENSRNOP00000017213 | DEP domain-containing MTOR-interacting protein. | Similar to KIAA0406-like protein (Predicted). | 0.995 |
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