Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ca3Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. (260 aa)    
Predicted Functional Partners:
Adipoq
Adiponectin, C1Q and collagen domain-containing.
   
  
 0.611
Cfd
Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family.
   
 
 0.591
Cabin1
Calcineurin-binding protein cabin-1; May be required for replication-independent chromatin assembly (By similarity). May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin.
      
 0.555
Rpf2
Ribosome production factor 2 homolog.
   
 
 0.549
Cyp2e1
Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
   
 
 0.542
Car1
Carbonic anhydrase 1; Reversible hydration of carbon dioxide.
  
 
0.538
Car2
Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton- coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6; Belongs to the alpha-carbonic anhydrase family.
  
  
0.535
Ca13
Carbonic anhydrase 13; Belongs to the alpha-carbonic anhydrase family.
  
  
0.526
Car7
RCG39078, isoform CRA_a; Belongs to the alpha-carbonic anhydrase family.
  
  
0.524
Stk40
Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
      
 0.515
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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