node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adipoq | Ca3 | ENSRNOP00000002492 | ENSRNOP00000014177 | Adiponectin, C1Q and collagen domain-containing. | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | 0.597 |
Adipoq | Cfd | ENSRNOP00000002492 | ENSRNOP00000015029 | Adiponectin, C1Q and collagen domain-containing. | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family. | 0.994 |
Adipoq | Cyp2e1 | ENSRNOP00000002492 | ENSRNOP00000016883 | Adiponectin, C1Q and collagen domain-containing. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.626 |
Bhmt | Ca3 | ENSRNOP00000015336 | ENSRNOP00000014177 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | 0.517 |
Bhmt | Cyp2e1 | ENSRNOP00000015336 | ENSRNOP00000016883 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.418 |
Ca13 | Ca3 | ENSRNOP00000031323 | ENSRNOP00000014177 | Carbonic anhydrase 13; Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | 0.519 |
Ca13 | Car1 | ENSRNOP00000031323 | ENSRNOP00000014267 | Carbonic anhydrase 13; Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 1; Reversible hydration of carbon dioxide. | 0.511 |
Ca13 | Car2 | ENSRNOP00000031323 | ENSRNOP00000013354 | Carbonic anhydrase 13; Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton- coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6; Belongs to the alpha-carbonic anhydrase family. | 0.576 |
Ca13 | Car7 | ENSRNOP00000031323 | ENSRNOP00000016521 | Carbonic anhydrase 13; Belongs to the alpha-carbonic anhydrase family. | RCG39078, isoform CRA_a; Belongs to the alpha-carbonic anhydrase family. | 0.548 |
Ca13 | Rpf2 | ENSRNOP00000031323 | ENSRNOP00000000717 | Carbonic anhydrase 13; Belongs to the alpha-carbonic anhydrase family. | Ribosome production factor 2 homolog. | 0.584 |
Ca3 | Adipoq | ENSRNOP00000014177 | ENSRNOP00000002492 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | Adiponectin, C1Q and collagen domain-containing. | 0.597 |
Ca3 | Bhmt | ENSRNOP00000014177 | ENSRNOP00000015336 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. | 0.517 |
Ca3 | Ca13 | ENSRNOP00000014177 | ENSRNOP00000031323 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 13; Belongs to the alpha-carbonic anhydrase family. | 0.519 |
Ca3 | Car1 | ENSRNOP00000014177 | ENSRNOP00000014267 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 1; Reversible hydration of carbon dioxide. | 0.535 |
Ca3 | Car2 | ENSRNOP00000014177 | ENSRNOP00000013354 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton- coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6; Belongs to the alpha-carbonic anhydrase family. | 0.529 |
Ca3 | Car7 | ENSRNOP00000014177 | ENSRNOP00000016521 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | RCG39078, isoform CRA_a; Belongs to the alpha-carbonic anhydrase family. | 0.538 |
Ca3 | Cfd | ENSRNOP00000014177 | ENSRNOP00000015029 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family. | 0.591 |
Ca3 | Cyp2e1 | ENSRNOP00000014177 | ENSRNOP00000016883 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.628 |
Ca3 | Myl1 | ENSRNOP00000014177 | ENSRNOP00000017838 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.513 |
Ca3 | Rpf2 | ENSRNOP00000014177 | ENSRNOP00000000717 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family. | Ribosome production factor 2 homolog. | 0.584 |