node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acot1 | Acot13 | ENSRNOP00000074406 | ENSRNOP00000024878 | Acyl-coenzyme A thioesterase 1. | Thioesterase superfamily member 2 (Predicted). | 0.614 |
Acot1 | Acot2 | ENSRNOP00000074406 | ENSRNOP00000013515 | Acyl-coenzyme A thioesterase 1. | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | 0.928 |
Acot1 | Acot3 | ENSRNOP00000074406 | ENSRNOP00000073103 | Acyl-coenzyme A thioesterase 1. | Acyl-CoA thioesterase 3. | 0.902 |
Acot1 | Acot4 | ENSRNOP00000074406 | ENSRNOP00000013754 | Acyl-coenzyme A thioesterase 1. | Acyl-CoA thioesterase 4. | 0.913 |
Acot1 | Acot5 | ENSRNOP00000074406 | ENSRNOP00000013760 | Acyl-coenzyme A thioesterase 1. | Acyl-CoA thioesterase 5. | 0.902 |
Acot1 | Acot7 | ENSRNOP00000074406 | ENSRNOP00000014213 | Acyl-coenzyme A thioesterase 1. | Cytosolic acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain. | 0.966 |
Acot1 | Acot8 | ENSRNOP00000074406 | ENSRNOP00000020740 | Acyl-coenzyme A thioesterase 1. | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 0.634 |
Acot1 | Tecr | ENSRNOP00000074406 | ENSRNOP00000035416 | Acyl-coenzyme A thioesterase 1. | Very-long-chain enoyl-CoA reductase; Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty aci [...] | 0.901 |
Acot1 | Them4 | ENSRNOP00000074406 | ENSRNOP00000028260 | Acyl-coenzyme A thioesterase 1. | Acyl-coenzyme A thioesterase THEM4; Has acyl-CoA thioesterase activity towards medium and long- chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity). | 0.908 |
Acot1 | Them5 | ENSRNOP00000074406 | ENSRNOP00000060470 | Acyl-coenzyme A thioesterase 1. | Thioesterase superfamily member 5. | 0.912 |
Acot13 | Acot1 | ENSRNOP00000024878 | ENSRNOP00000074406 | Thioesterase superfamily member 2 (Predicted). | Acyl-coenzyme A thioesterase 1. | 0.614 |
Acot13 | Acot2 | ENSRNOP00000024878 | ENSRNOP00000013515 | Thioesterase superfamily member 2 (Predicted). | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | 0.711 |
Acot13 | Acot3 | ENSRNOP00000024878 | ENSRNOP00000073103 | Thioesterase superfamily member 2 (Predicted). | Acyl-CoA thioesterase 3. | 0.797 |
Acot13 | Acot4 | ENSRNOP00000024878 | ENSRNOP00000013754 | Thioesterase superfamily member 2 (Predicted). | Acyl-CoA thioesterase 4. | 0.653 |
Acot13 | Acot5 | ENSRNOP00000024878 | ENSRNOP00000013760 | Thioesterase superfamily member 2 (Predicted). | Acyl-CoA thioesterase 5. | 0.653 |
Acot13 | Acot7 | ENSRNOP00000024878 | ENSRNOP00000014213 | Thioesterase superfamily member 2 (Predicted). | Cytosolic acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain. | 0.821 |
Acot13 | Acot8 | ENSRNOP00000024878 | ENSRNOP00000020740 | Thioesterase superfamily member 2 (Predicted). | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 0.830 |
Acot13 | Them5 | ENSRNOP00000024878 | ENSRNOP00000060470 | Thioesterase superfamily member 2 (Predicted). | Thioesterase superfamily member 5. | 0.569 |
Acot2 | Acot1 | ENSRNOP00000013515 | ENSRNOP00000074406 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | Acyl-coenzyme A thioesterase 1. | 0.928 |
Acot2 | Acot13 | ENSRNOP00000013515 | ENSRNOP00000024878 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | Thioesterase superfamily member 2 (Predicted). | 0.711 |