Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Car1Carbonic anhydrase 1; Reversible hydration of carbon dioxide. (261 aa)    
Predicted Functional Partners:
Ahsp
Erythroid associated factor (Predicted).
   
  
 0.783
Car2
Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton- coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6; Belongs to the alpha-carbonic anhydrase family.
  
 
0.776
Epb42
Erythrocyte protein band 4.2 (Predicted).
   
  
 0.763
Slc4a1
Band 3 anion transport protein; Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride- bicarbonate exch [...]
   
 
 0.738
Alas2
5-aminolevulinate synthase, erythroid-specific, mitochondrial.
   
  
 0.610
Rpf2
Ribosome production factor 2 homolog.
   
 
 0.549
Ca3
Carbonic anhydrase 3; Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress; Belongs to the alpha-carbonic anhydrase family.
  
 
0.538
Cebpz
CCAAT/enhancer-binding protein zeta.
   
  
 0.527
Car7
RCG39078, isoform CRA_a; Belongs to the alpha-carbonic anhydrase family.
  
 
0.525
Ca4
Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity). Belongs to the alpha-carbonic anhydrase family.
  
0.516
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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