node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arntl | Noct | ENSRNOP00000042830 | ENSRNOP00000014348 | Aryl hydrocarbon receptor nuclear translocator-like protein 1; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...] | Nocturnin; Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenes [...] | 0.733 |
Cdc73 | Noct | ENSRNOP00000004495 | ENSRNOP00000014348 | Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional [...] | Nocturnin; Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenes [...] | 0.692 |
Cnot1 | Cnot2 | ENSRNOP00000016563 | ENSRNOP00000074023 | CCR4-NOT transcription complex, subunit 1. | CCR4-NOT transcription complex, subunit 2. | 0.999 |
Cnot1 | Cnot3 | ENSRNOP00000016563 | ENSRNOP00000075261 | CCR4-NOT transcription complex, subunit 1. | CCR4-NOT transcription complex, subunit 3. | 0.999 |
Cnot1 | Cnot7 | ENSRNOP00000016563 | ENSRNOP00000016882 | CCR4-NOT transcription complex, subunit 1. | CCR4-NOT transcription complex, subunit 7. | 0.998 |
Cnot1 | Cnot9 | ENSRNOP00000016563 | ENSRNOP00000021548 | CCR4-NOT transcription complex, subunit 1. | CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. Enhances ligand- dependent transcriptional activity of nuclear hormone receptors. May play a role in cell d [...] | 0.999 |
Cnot1 | Ddx6 | ENSRNOP00000016563 | ENSRNOP00000073900 | CCR4-NOT transcription complex, subunit 1. | DEAD-box helicase 6; Belongs to the DEAD box helicase family. | 0.993 |
Cnot1 | Noct | ENSRNOP00000016563 | ENSRNOP00000014348 | CCR4-NOT transcription complex, subunit 1. | Nocturnin; Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenes [...] | 0.851 |
Cnot2 | Cnot1 | ENSRNOP00000074023 | ENSRNOP00000016563 | CCR4-NOT transcription complex, subunit 2. | CCR4-NOT transcription complex, subunit 1. | 0.999 |
Cnot2 | Cnot3 | ENSRNOP00000074023 | ENSRNOP00000075261 | CCR4-NOT transcription complex, subunit 2. | CCR4-NOT transcription complex, subunit 3. | 0.998 |
Cnot2 | Cnot7 | ENSRNOP00000074023 | ENSRNOP00000016882 | CCR4-NOT transcription complex, subunit 2. | CCR4-NOT transcription complex, subunit 7. | 0.995 |
Cnot2 | Cnot9 | ENSRNOP00000074023 | ENSRNOP00000021548 | CCR4-NOT transcription complex, subunit 2. | CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. Enhances ligand- dependent transcriptional activity of nuclear hormone receptors. May play a role in cell d [...] | 0.999 |
Cnot2 | Ddx6 | ENSRNOP00000074023 | ENSRNOP00000073900 | CCR4-NOT transcription complex, subunit 2. | DEAD-box helicase 6; Belongs to the DEAD box helicase family. | 0.662 |
Cnot2 | Noct | ENSRNOP00000074023 | ENSRNOP00000014348 | CCR4-NOT transcription complex, subunit 2. | Nocturnin; Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenes [...] | 0.715 |
Cnot3 | Cnot1 | ENSRNOP00000075261 | ENSRNOP00000016563 | CCR4-NOT transcription complex, subunit 3. | CCR4-NOT transcription complex, subunit 1. | 0.999 |
Cnot3 | Cnot2 | ENSRNOP00000075261 | ENSRNOP00000074023 | CCR4-NOT transcription complex, subunit 3. | CCR4-NOT transcription complex, subunit 2. | 0.998 |
Cnot3 | Cnot7 | ENSRNOP00000075261 | ENSRNOP00000016882 | CCR4-NOT transcription complex, subunit 3. | CCR4-NOT transcription complex, subunit 7. | 0.992 |
Cnot3 | Cnot9 | ENSRNOP00000075261 | ENSRNOP00000021548 | CCR4-NOT transcription complex, subunit 3. | CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. Enhances ligand- dependent transcriptional activity of nuclear hormone receptors. May play a role in cell d [...] | 0.999 |
Cnot3 | Ddx6 | ENSRNOP00000075261 | ENSRNOP00000073900 | CCR4-NOT transcription complex, subunit 3. | DEAD-box helicase 6; Belongs to the DEAD box helicase family. | 0.895 |
Cnot3 | Noct | ENSRNOP00000075261 | ENSRNOP00000014348 | CCR4-NOT transcription complex, subunit 3. | Nocturnin; Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenes [...] | 0.719 |