| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Abca3 | Aqp5 | ENSRNOP00000071944 | ENSRNOP00000073596 | ATP-binding cassette subfamily A member 3. | Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). | 0.573 |
| Abca3 | Nkx2-1 | ENSRNOP00000071944 | ENSRNOP00000011453 | ATP-binding cassette subfamily A member 3. | Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circad [...] | 0.562 |
| Abca3 | Scgb1a1 | ENSRNOP00000071944 | ENSRNOP00000027342 | ATP-binding cassette subfamily A member 3. | Uteroglobin; Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. | 0.590 |
| Abca3 | Scgb3a2 | ENSRNOP00000071944 | ENSRNOP00000038104 | ATP-binding cassette subfamily A member 3. | Pneumo secretory protein 1, isoform CRA_b. | 0.559 |
| Abca3 | Sftpa1 | ENSRNOP00000071944 | ENSRNOP00000039850 | ATP-binding cassette subfamily A member 3. | Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. | 0.636 |
| Abca3 | Sftpb | ENSRNOP00000071944 | ENSRNOP00000014505 | ATP-binding cassette subfamily A member 3. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.817 |
| Abca3 | Sftpc | ENSRNOP00000071944 | ENSRNOP00000015032 | ATP-binding cassette subfamily A member 3. | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.779 |
| Abca3 | Sftpd | ENSRNOP00000071944 | ENSRNOP00000069079 | ATP-binding cassette subfamily A member 3. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties; Belongs to the SFTPD family. | 0.582 |
| Aqp5 | Abca3 | ENSRNOP00000073596 | ENSRNOP00000071944 | Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). | ATP-binding cassette subfamily A member 3. | 0.573 |
| Aqp5 | Nkx2-1 | ENSRNOP00000073596 | ENSRNOP00000011453 | Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). | Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circad [...] | 0.625 |
| Aqp5 | Scgb1a1 | ENSRNOP00000073596 | ENSRNOP00000027342 | Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). | Uteroglobin; Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. | 0.761 |
| Aqp5 | Scgb3a2 | ENSRNOP00000073596 | ENSRNOP00000038104 | Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). | Pneumo secretory protein 1, isoform CRA_b. | 0.614 |
| Aqp5 | Sftpa1 | ENSRNOP00000073596 | ENSRNOP00000039850 | Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). | Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. | 0.638 |
| Aqp5 | Sftpb | ENSRNOP00000073596 | ENSRNOP00000014505 | Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.813 |
| Aqp5 | Sftpc | ENSRNOP00000073596 | ENSRNOP00000015032 | Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.889 |
| Aqp5 | Sftpd | ENSRNOP00000073596 | ENSRNOP00000069079 | Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties; Belongs to the SFTPD family. | 0.705 |
| Ctsh | Napsa | ENSRNOP00000074611 | ENSRNOP00000026992 | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. | Napsin A aspartic peptidase, isoform CRA_a; Belongs to the peptidase A1 family. | 0.944 |
| Ctsh | Sftpb | ENSRNOP00000074611 | ENSRNOP00000014505 | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.892 |
| Ctsh | Sftpc | ENSRNOP00000074611 | ENSRNOP00000015032 | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.828 |
| Napsa | Ctsh | ENSRNOP00000026992 | ENSRNOP00000074611 | Napsin A aspartic peptidase, isoform CRA_a; Belongs to the peptidase A1 family. | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. | 0.944 |
