node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cma1 | Cpa2 | ENSRNOP00000061330 | ENSRNOP00000038495 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Carboxypeptidase A2. | 0.407 |
Cma1 | Cpa3 | ENSRNOP00000061330 | ENSRNOP00000014970 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Mast cell carboxypeptidase A. | 0.977 |
Cma1 | Ctsg | ENSRNOP00000061330 | ENSRNOP00000056429 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Cathepsin G. | 0.459 |
Cma1 | Fcer1a | ENSRNOP00000061330 | ENSRNOP00000069343 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | 0.743 |
Cma1 | Mcpt1 | ENSRNOP00000061330 | ENSRNOP00000027931 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Mast cell protease 2; This enzyme, isolated from small intestine, specifically inactivates the apo forms of a certain group of intracellular pyridoxal phosphate-requiring enzymes. It has chymotrypsin-like specificity towards small substrates. | 0.415 |
Cma1 | Mcpt1l1 | ENSRNOP00000061330 | ENSRNOP00000069831 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Mast cell protease 1; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. May participate in generating perivascular beta-protein which ultimately aggregates into amyloid-beta deposits. | 0.988 |
Cma1 | Ms4a2 | ENSRNOP00000061330 | ENSRNOP00000028491 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor- bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy; Belongs to the MS4A family. | 0.562 |
Cma1 | Tpsab1 | ENSRNOP00000061330 | ENSRNOP00000025095 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity (By similarity). Belongs to the peptidase S1 family. Tryptase subfamily. | 0.638 |
Cma1 | Tpsb2 | ENSRNOP00000061330 | ENSRNOP00000025220 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | Tryptase beta-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Plays a role in innate immunity; Belongs to the peptidase S1 family. Tryptase subfamily. | 0.946 |
Cpa1 | Cpa2 | ENSRNOP00000014465 | ENSRNOP00000038495 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | Carboxypeptidase A2. | 0.953 |
Cpa1 | Cpa3 | ENSRNOP00000014465 | ENSRNOP00000014970 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | Mast cell carboxypeptidase A. | 0.921 |
Cpa2 | Cma1 | ENSRNOP00000038495 | ENSRNOP00000061330 | Carboxypeptidase A2. | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.407 |
Cpa2 | Cpa1 | ENSRNOP00000038495 | ENSRNOP00000014465 | Carboxypeptidase A2. | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | 0.953 |
Cpa2 | Cpa3 | ENSRNOP00000038495 | ENSRNOP00000014970 | Carboxypeptidase A2. | Mast cell carboxypeptidase A. | 0.918 |
Cpa3 | Cma1 | ENSRNOP00000014970 | ENSRNOP00000061330 | Mast cell carboxypeptidase A. | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.977 |
Cpa3 | Cpa1 | ENSRNOP00000014970 | ENSRNOP00000014465 | Mast cell carboxypeptidase A. | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | 0.921 |
Cpa3 | Cpa2 | ENSRNOP00000014970 | ENSRNOP00000038495 | Mast cell carboxypeptidase A. | Carboxypeptidase A2. | 0.918 |
Cpa3 | Ctsg | ENSRNOP00000014970 | ENSRNOP00000056429 | Mast cell carboxypeptidase A. | Cathepsin G. | 0.777 |
Cpa3 | Fcer1a | ENSRNOP00000014970 | ENSRNOP00000069343 | Mast cell carboxypeptidase A. | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | 0.835 |
Cpa3 | Mcpt1 | ENSRNOP00000014970 | ENSRNOP00000027931 | Mast cell carboxypeptidase A. | Mast cell protease 2; This enzyme, isolated from small intestine, specifically inactivates the apo forms of a certain group of intracellular pyridoxal phosphate-requiring enzymes. It has chymotrypsin-like specificity towards small substrates. | 0.776 |