| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ccl3 | Ccl4 | ENSRNOP00000015139 | ENSRNOP00000015199 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | 0.961 |
| Ccl3 | Ccr1 | ENSRNOP00000015139 | ENSRNOP00000008772 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | 0.973 |
| Ccl3 | Ccr3 | ENSRNOP00000015139 | ENSRNOP00000008809 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.970 |
| Ccl3 | Ccr5 | ENSRNOP00000015139 | ENSRNOP00000073121 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.990 |
| Ccl3 | Ccr7 | ENSRNOP00000015139 | ENSRNOP00000014163 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | Chemokine receptor 7-like protein; Belongs to the G-protein coupled receptor 1 family. | 0.959 |
| Ccl3 | Ccr8 | ENSRNOP00000015139 | ENSRNOP00000029724 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. | 0.950 |
| Ccl3 | Cx3cr1 | ENSRNOP00000015139 | ENSRNOP00000025019 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. | 0.975 |
| Ccl3 | Cxcr2 | ENSRNOP00000015139 | ENSRNOP00000019109 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). | 0.956 |
| Ccl3 | Cxcr3 | ENSRNOP00000015139 | ENSRNOP00000004406 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.964 |
| Ccl3 | Cxcr4 | ENSRNOP00000015139 | ENSRNOP00000005143 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.960 |
| Ccl4 | Ccl3 | ENSRNOP00000015199 | ENSRNOP00000015139 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. | 0.961 |
| Ccl4 | Ccr1 | ENSRNOP00000015199 | ENSRNOP00000008772 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | 0.938 |
| Ccl4 | Ccr3 | ENSRNOP00000015199 | ENSRNOP00000008809 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.970 |
| Ccl4 | Ccr5 | ENSRNOP00000015199 | ENSRNOP00000073121 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.996 |
| Ccl4 | Ccr7 | ENSRNOP00000015199 | ENSRNOP00000014163 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | Chemokine receptor 7-like protein; Belongs to the G-protein coupled receptor 1 family. | 0.952 |
| Ccl4 | Ccr8 | ENSRNOP00000015199 | ENSRNOP00000029724 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. | 0.925 |
| Ccl4 | Cx3cr1 | ENSRNOP00000015199 | ENSRNOP00000025019 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. | 0.922 |
| Ccl4 | Cxcr2 | ENSRNOP00000015199 | ENSRNOP00000019109 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). | 0.855 |
| Ccl4 | Cxcr3 | ENSRNOP00000015199 | ENSRNOP00000004406 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.954 |
| Ccl4 | Cxcr4 | ENSRNOP00000015199 | ENSRNOP00000005143 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.955 |
