node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Anxa5 | Cybb | ENSRNOP00000019552 | ENSRNOP00000031063 | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | Cytochrome b-245, beta polypeptide, isoform CRA_a. | 0.425 |
Anxa5 | S100a9 | ENSRNOP00000019552 | ENSRNOP00000015351 | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] | 0.650 |
Anxa5 | Tlr4 | ENSRNOP00000019552 | ENSRNOP00000014020 | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.600 |
Camp | Ngp | ENSRNOP00000028130 | ENSRNOP00000032468 | Cathelicidin antimicrobial peptide. | Neutrophilic granule protein (Predicted). | 0.978 |
Camp | S100a8 | ENSRNOP00000028130 | ENSRNOP00000015473 | Cathelicidin antimicrobial peptide. | Protein S100-A8; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH- oxidase. Activates NADPH-oxidase by facilitat [...] | 0.646 |
Camp | S100a9 | ENSRNOP00000028130 | ENSRNOP00000015351 | Cathelicidin antimicrobial peptide. | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] | 0.693 |
Camp | Tlr4 | ENSRNOP00000028130 | ENSRNOP00000014020 | Cathelicidin antimicrobial peptide. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.452 |
Cybb | Anxa5 | ENSRNOP00000031063 | ENSRNOP00000019552 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | 0.425 |
Cybb | Ncf4 | ENSRNOP00000031063 | ENSRNOP00000009544 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Similar to neutrophil cytosolic factor 4, isoform CRA_a. | 0.996 |
Cybb | Rac2 | ENSRNOP00000031063 | ENSRNOP00000009994 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). | 0.999 |
Cybb | S100a8 | ENSRNOP00000031063 | ENSRNOP00000015473 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Protein S100-A8; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH- oxidase. Activates NADPH-oxidase by facilitat [...] | 0.588 |
Cybb | S100a9 | ENSRNOP00000031063 | ENSRNOP00000015351 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] | 0.647 |
Cybb | Tlr4 | ENSRNOP00000031063 | ENSRNOP00000014020 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.875 |
Hspa9 | S100a9 | ENSRNOP00000026696 | ENSRNOP00000015351 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] | 0.591 |
Hspa9 | Tlr4 | ENSRNOP00000026696 | ENSRNOP00000014020 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.916 |
Ncf4 | Cybb | ENSRNOP00000009544 | ENSRNOP00000031063 | Similar to neutrophil cytosolic factor 4, isoform CRA_a. | Cytochrome b-245, beta polypeptide, isoform CRA_a. | 0.996 |
Ncf4 | Rac2 | ENSRNOP00000009544 | ENSRNOP00000009994 | Similar to neutrophil cytosolic factor 4, isoform CRA_a. | Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). | 0.996 |
Ncf4 | S100a8 | ENSRNOP00000009544 | ENSRNOP00000015473 | Similar to neutrophil cytosolic factor 4, isoform CRA_a. | Protein S100-A8; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH- oxidase. Activates NADPH-oxidase by facilitat [...] | 0.589 |
Ncf4 | S100a9 | ENSRNOP00000009544 | ENSRNOP00000015351 | Similar to neutrophil cytosolic factor 4, isoform CRA_a. | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] | 0.587 |
Ngp | Camp | ENSRNOP00000032468 | ENSRNOP00000028130 | Neutrophilic granule protein (Predicted). | Cathelicidin antimicrobial peptide. | 0.978 |