STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ankrd44Ankyrin repeat domain 44. (993 aa)    
Predicted Functional Partners:
Ppp6r1
Protein phosphatase 6, regulatory subunit 1.
    
 
 0.735
Ppp6r3
Protein phosphatase 6, regulatory subunit 3.
    
 
 0.660
Ppp6r2
Protein phosphatase 6, regulatory subunit 2.
    
 
 0.658
Ppp6c
Serine/threonine-protein phosphatase 6 catalytic subunit; Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential [...]
    
 
 0.651
Mars2-2
methionyl-tRNA synthetase 2, mitochondrial.
    
 
 0.634
Tppp2
Similar to chromosome 14 open reading frame 8 (Predicted).
    
 
 0.544
Tnrc18
Trinucleotide repeat-containing 18.
    
 
 0.540
Rftn2
Similar to 3222401M22Rik protein (Predicted), isoform CRA_c.
      
 0.535
Pram1
PML-RARA-regulated adaptor molecule 1.
      
 0.471
Clec1a
Similar to C-type lectin-like receptor-1 (Predicted).
    
 
 0.467
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.