STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cnn3Calponin-3; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (330 aa)    
Predicted Functional Partners:
Wdr90
WD repeat domain 90.
    
 
 0.753
Pdlim4
PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (By similarity). Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...]
   
 
 0.583
Pacrgl
Similar to RIKEN cDNA 4933428G09 (Predicted), isoform CRA_b.
    
 
 0.574
Bcl2l10
Bcl-2-like protein 10; Promotes cell survival. Suppresses apoptosis (By similarity). Belongs to the Bcl-2 family.
   
  
 0.572
Calb2
Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons.
   
 
 0.561
Pls3
Plastin-3; Actin-bundling protein.
   
 
 0.557
Smarca2
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 2.
   
  
 0.554
Dstn
Destrin; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner; Belongs to the actin-binding proteins ADF family.
   
 
 0.529
Tmod3
RCG25684, isoform CRA_a.
   
  
 0.529
Parp10
Poly [ADP-ribose] polymerase.
   
  
 0.522
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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