node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1rl | C1s | ENSRNOP00000015679 | ENSRNOP00000016330 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | 0.935 |
C1rl | C4a | ENSRNOP00000015679 | ENSRNOP00000066721 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | Complement C4A. | 0.431 |
C1rl | C8a | ENSRNOP00000015679 | ENSRNOP00000063871 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | Complement component 8, alpha polypeptide (Predicted). | 0.554 |
C1rl | C8b | ENSRNOP00000015679 | ENSRNOP00000010100 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. | 0.445 |
C1rl | Cma1 | ENSRNOP00000015679 | ENSRNOP00000061330 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.447 |
C1rl | Ddhd2 | ENSRNOP00000015679 | ENSRNOP00000020832 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | DDHD domain-containing 2. | 0.463 |
C1rl | Gp1ba | ENSRNOP00000015679 | ENSRNOP00000053510 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | Glycoprotein Ib platelet subunit alpha. | 0.437 |
C1rl | Itih4 | ENSRNOP00000015679 | ENSRNOP00000058007 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | Inter alpha-trypsin inhibitor, heavy chain 4, isoform CRA_a. | 0.447 |
C1rl | LOC100911881 | ENSRNOP00000015679 | ENSRNOP00000048948 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | Chitinase domain-containing protein 1; Belongs to the glycosyl hydrolase 18 family. | 0.560 |
C1rl | Zfp763 | ENSRNOP00000015679 | ENSRNOP00000070323 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | Zinc finger protein 763. | 0.523 |
C1s | C1rl | ENSRNOP00000016330 | ENSRNOP00000015679 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | 0.935 |
C1s | C4a | ENSRNOP00000016330 | ENSRNOP00000066721 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement C4A. | 0.924 |
C1s | C8a | ENSRNOP00000016330 | ENSRNOP00000063871 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement component 8, alpha polypeptide (Predicted). | 0.654 |
C1s | C8b | ENSRNOP00000016330 | ENSRNOP00000010100 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. | 0.550 |
C4a | C1rl | ENSRNOP00000066721 | ENSRNOP00000015679 | Complement C4A. | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | 0.431 |
C4a | C1s | ENSRNOP00000066721 | ENSRNOP00000016330 | Complement C4A. | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | 0.924 |
C4a | C8a | ENSRNOP00000066721 | ENSRNOP00000063871 | Complement C4A. | Complement component 8, alpha polypeptide (Predicted). | 0.537 |
C4a | C8b | ENSRNOP00000066721 | ENSRNOP00000010100 | Complement C4A. | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. | 0.623 |
C8a | C1rl | ENSRNOP00000063871 | ENSRNOP00000015679 | Complement component 8, alpha polypeptide (Predicted). | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family. | 0.554 |
C8a | C1s | ENSRNOP00000063871 | ENSRNOP00000016330 | Complement component 8, alpha polypeptide (Predicted). | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | 0.654 |