| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aadat | Acy1 | ENSRNOP00000015974 | ENSRNOP00000015852 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | 0.700 |
| Aadat | Agmat | ENSRNOP00000015974 | ENSRNOP00000016646 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.432 |
| Aadat | Ass1 | ENSRNOP00000015974 | ENSRNOP00000076301 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.471 |
| Acy1 | Aadat | ENSRNOP00000015852 | ENSRNOP00000015974 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.700 |
| Acy1 | Agmat | ENSRNOP00000015852 | ENSRNOP00000016646 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.792 |
| Acy1 | Arg1 | ENSRNOP00000015852 | ENSRNOP00000017911 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.900 |
| Acy1 | Arg2 | ENSRNOP00000015852 | ENSRNOP00000073568 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.900 |
| Acy1 | Aspa | ENSRNOP00000015852 | ENSRNOP00000072876 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity). | 0.772 |
| Acy1 | Ass1 | ENSRNOP00000015852 | ENSRNOP00000076301 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.819 |
| Acy1 | Nudt1 | ENSRNOP00000015852 | ENSRNOP00000001700 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | 7,8-dihydro-8-oxoguanine triphosphatase; Antimutagenic. Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo- dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo- ATP (By similarity). [...] | 0.759 |
| Acy1 | Otc | ENSRNOP00000015852 | ENSRNOP00000004686 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.931 |
| Acy1 | Ppme1 | ENSRNOP00000015852 | ENSRNOP00000023649 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | 0.729 |
| Acy1 | Ttc1 | ENSRNOP00000015852 | ENSRNOP00000005304 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Tetratricopeptide repeat domain 1. | 0.692 |
| Agmat | Aadat | ENSRNOP00000016646 | ENSRNOP00000015974 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.432 |
| Agmat | Acy1 | ENSRNOP00000016646 | ENSRNOP00000015852 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | 0.792 |
| Agmat | Arg1 | ENSRNOP00000016646 | ENSRNOP00000017911 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.614 |
| Agmat | Arg2 | ENSRNOP00000016646 | ENSRNOP00000073568 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.614 |
| Agmat | Ass1 | ENSRNOP00000016646 | ENSRNOP00000076301 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.727 |
| Agmat | Otc | ENSRNOP00000016646 | ENSRNOP00000004686 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.841 |
| Arg1 | Acy1 | ENSRNOP00000017911 | ENSRNOP00000015852 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | 0.900 |
