node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Braf | Cdc37l1 | ENSRNOP00000014604 | ENSRNOP00000016000 | B-Raf proto-oncogene, serine/threonine kinase. | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | 0.698 |
Braf | D3ZXC7_RAT | ENSRNOP00000014604 | ENSRNOP00000004806 | B-Raf proto-oncogene, serine/threonine kinase. | Uncharacterized protein. | 0.599 |
Braf | Hsp90ab1 | ENSRNOP00000014604 | ENSRNOP00000026920 | B-Raf proto-oncogene, serine/threonine kinase. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.638 |
Braf | LOC103692716 | ENSRNOP00000014604 | ENSRNOP00000009556 | B-Raf proto-oncogene, serine/threonine kinase. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.599 |
Braf | Ppp5c | ENSRNOP00000014604 | ENSRNOP00000023078 | B-Raf proto-oncogene, serine/threonine kinase. | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Pa [...] | 0.833 |
Cdc37l1 | Braf | ENSRNOP00000016000 | ENSRNOP00000014604 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | B-Raf proto-oncogene, serine/threonine kinase. | 0.698 |
Cdc37l1 | D3ZXC7_RAT | ENSRNOP00000016000 | ENSRNOP00000004806 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Uncharacterized protein. | 0.631 |
Cdc37l1 | Hsp90ab1 | ENSRNOP00000016000 | ENSRNOP00000026920 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.631 |
Cdc37l1 | Hsp90b1 | ENSRNOP00000016000 | ENSRNOP00000034846 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. | 0.706 |
Cdc37l1 | LOC103692716 | ENSRNOP00000016000 | ENSRNOP00000009556 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.631 |
Cdc37l1 | Plekha3 | ENSRNOP00000016000 | ENSRNOP00000016132 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Pleckstrin homology domain-containing A3. | 0.661 |
Cdc37l1 | Ppp5c | ENSRNOP00000016000 | ENSRNOP00000023078 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Pa [...] | 0.799 |
Cdc37l1 | Spp2 | ENSRNOP00000016000 | ENSRNOP00000075164 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Secreted phosphoprotein 24; Could coordinate an aspect of bone turnover; Belongs to the SPP2 family. | 0.664 |
Cdc37l1 | Stip1 | ENSRNOP00000016000 | ENSRNOP00000028743 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1 (By similarity). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. | 0.766 |
Cdc37l1 | Zc2hc1a | ENSRNOP00000016000 | ENSRNOP00000060953 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Family with sequence similarity 164, member A. | 0.638 |
D3ZXC7_RAT | Braf | ENSRNOP00000004806 | ENSRNOP00000014604 | Uncharacterized protein. | B-Raf proto-oncogene, serine/threonine kinase. | 0.599 |
D3ZXC7_RAT | Cdc37l1 | ENSRNOP00000004806 | ENSRNOP00000016000 | Uncharacterized protein. | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | 0.631 |
D3ZXC7_RAT | Ppp5c | ENSRNOP00000004806 | ENSRNOP00000023078 | Uncharacterized protein. | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Pa [...] | 0.724 |
D3ZXC7_RAT | Stip1 | ENSRNOP00000004806 | ENSRNOP00000028743 | Uncharacterized protein. | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1 (By similarity). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. | 0.913 |
Hsp90ab1 | Braf | ENSRNOP00000026920 | ENSRNOP00000014604 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | B-Raf proto-oncogene, serine/threonine kinase. | 0.638 |