node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ash2l | Dpy30 | ENSRNOP00000068617 | ENSRNOP00000070382 | ASH2-like histone lysine methyltransferase complex subunit. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | 0.999 |
Ash2l | Kmt2a | ENSRNOP00000068617 | ENSRNOP00000020573 | ASH2-like histone lysine methyltransferase complex subunit. | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | 0.999 |
Ash2l | Kmt2b | ENSRNOP00000068617 | ENSRNOP00000071806 | ASH2-like histone lysine methyltransferase complex subunit. | Lysine methyltransferase 2B. | 0.957 |
Ash2l | Men1 | ENSRNOP00000068617 | ENSRNOP00000028592 | ASH2-like histone lysine methyltransferase complex subunit. | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Represses JUND- mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair (By similarity). Plays a role in TGFB1-mediated inhibi [...] | 0.974 |
Ash2l | Psip1 | ENSRNOP00000068617 | ENSRNOP00000016130 | ASH2-like histone lysine methyltransferase complex subunit. | PC4 and SFRS1-interacting protein; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). | 0.754 |
Ash2l | Rbbp5 | ENSRNOP00000068617 | ENSRNOP00000031945 | ASH2-like histone lysine methyltransferase complex subunit. | RB-binding protein 5, histone lysine methyltransferase complex subunit. | 0.999 |
Brd4 | Kmt2a | ENSRNOP00000008963 | ENSRNOP00000020573 | Bromodomain-containing 4. | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | 0.610 |
Brd4 | Kmt2b | ENSRNOP00000008963 | ENSRNOP00000071806 | Bromodomain-containing 4. | Lysine methyltransferase 2B. | 0.409 |
Brd4 | Psip1 | ENSRNOP00000008963 | ENSRNOP00000016130 | Bromodomain-containing 4. | PC4 and SFRS1-interacting protein; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). | 0.694 |
Brd4 | Srsf1 | ENSRNOP00000008963 | ENSRNOP00000064933 | Bromodomain-containing 4. | Serine and arginine-rich-splicing factor 1. | 0.411 |
Dpy30 | Ash2l | ENSRNOP00000070382 | ENSRNOP00000068617 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | ASH2-like histone lysine methyltransferase complex subunit. | 0.999 |
Dpy30 | Kmt2a | ENSRNOP00000070382 | ENSRNOP00000020573 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | 0.980 |
Dpy30 | Kmt2b | ENSRNOP00000070382 | ENSRNOP00000071806 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | Lysine methyltransferase 2B. | 0.908 |
Dpy30 | Men1 | ENSRNOP00000070382 | ENSRNOP00000028592 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Represses JUND- mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair (By similarity). Plays a role in TGFB1-mediated inhibi [...] | 0.913 |
Dpy30 | Psip1 | ENSRNOP00000070382 | ENSRNOP00000016130 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | PC4 and SFRS1-interacting protein; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). | 0.664 |
Dpy30 | Rbbp5 | ENSRNOP00000070382 | ENSRNOP00000031945 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | RB-binding protein 5, histone lysine methyltransferase complex subunit. | 0.999 |
Kmt2a | Ash2l | ENSRNOP00000020573 | ENSRNOP00000068617 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | ASH2-like histone lysine methyltransferase complex subunit. | 0.999 |
Kmt2a | Brd4 | ENSRNOP00000020573 | ENSRNOP00000008963 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | Bromodomain-containing 4. | 0.610 |
Kmt2a | Dpy30 | ENSRNOP00000020573 | ENSRNOP00000070382 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | 0.980 |
Kmt2a | Kmt2b | ENSRNOP00000020573 | ENSRNOP00000071806 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | Lysine methyltransferase 2B. | 0.887 |