node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mrpl21 | Mrps6 | ENSRNOP00000018848 | ENSRNOP00000071228 | Mitochondrial ribosomal protein L21 (Predicted), isoform CRA_a. | Mitochondrial ribosomal protein S6. | 0.998 |
Mrpl21 | Ssbp1 | ENSRNOP00000018848 | ENSRNOP00000016217 | Mitochondrial ribosomal protein L21 (Predicted), isoform CRA_a. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.888 |
Mrps6 | Mrpl21 | ENSRNOP00000071228 | ENSRNOP00000018848 | Mitochondrial ribosomal protein S6. | Mitochondrial ribosomal protein L21 (Predicted), isoform CRA_a. | 0.998 |
Mrps6 | Rnaseh1 | ENSRNOP00000071228 | ENSRNOP00000011819 | Mitochondrial ribosomal protein S6. | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II; Belongs to the RNase H family. | 0.471 |
Mrps6 | Ssbp1 | ENSRNOP00000071228 | ENSRNOP00000016217 | Mitochondrial ribosomal protein S6. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.966 |
Polg | Polg2 | ENSRNOP00000047900 | ENSRNOP00000018394 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). | Polymerase (DNA directed), gamma 2, accessory subunit (Predicted). | 0.992 |
Polg | Polrmt | ENSRNOP00000047900 | ENSRNOP00000032448 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. | 0.820 |
Polg | Rnaseh1 | ENSRNOP00000047900 | ENSRNOP00000011819 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II; Belongs to the RNase H family. | 0.697 |
Polg | Ssbp1 | ENSRNOP00000047900 | ENSRNOP00000016217 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.962 |
Polg | Tfam | ENSRNOP00000047900 | ENSRNOP00000000753 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). | Transcription factor A, mitochondrial; Isoform mitochondrial binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- template strand. Required for accurate and efficient promoter recognition by the mito [...] | 0.914 |
Polg | Twnk | ENSRNOP00000047900 | ENSRNOP00000034807 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). | Progressive external ophthalmoplegia 1 homolog (Human) (Predicted). | 0.964 |
Polg2 | Polg | ENSRNOP00000018394 | ENSRNOP00000047900 | Polymerase (DNA directed), gamma 2, accessory subunit (Predicted). | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). | 0.992 |
Polg2 | Polrmt | ENSRNOP00000018394 | ENSRNOP00000032448 | Polymerase (DNA directed), gamma 2, accessory subunit (Predicted). | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. | 0.802 |
Polg2 | Rnaseh1 | ENSRNOP00000018394 | ENSRNOP00000011819 | Polymerase (DNA directed), gamma 2, accessory subunit (Predicted). | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II; Belongs to the RNase H family. | 0.693 |
Polg2 | Ssbp1 | ENSRNOP00000018394 | ENSRNOP00000016217 | Polymerase (DNA directed), gamma 2, accessory subunit (Predicted). | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.787 |
Polg2 | Tfam | ENSRNOP00000018394 | ENSRNOP00000000753 | Polymerase (DNA directed), gamma 2, accessory subunit (Predicted). | Transcription factor A, mitochondrial; Isoform mitochondrial binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- template strand. Required for accurate and efficient promoter recognition by the mito [...] | 0.682 |
Polg2 | Twnk | ENSRNOP00000018394 | ENSRNOP00000034807 | Polymerase (DNA directed), gamma 2, accessory subunit (Predicted). | Progressive external ophthalmoplegia 1 homolog (Human) (Predicted). | 0.870 |
Polrmt | Polg | ENSRNOP00000032448 | ENSRNOP00000047900 | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). | 0.820 |
Polrmt | Polg2 | ENSRNOP00000032448 | ENSRNOP00000018394 | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. | Polymerase (DNA directed), gamma 2, accessory subunit (Predicted). | 0.802 |
Polrmt | Rnaseh1 | ENSRNOP00000032448 | ENSRNOP00000011819 | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II; Belongs to the RNase H family. | 0.616 |