node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fads3 | Setd6 | ENSRNOP00000027693 | ENSRNOP00000016626 | Fatty acid desaturase 3; Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate) at carbon 13 to generate (11E,13Z)-octadecadienoate, likely participating in the biohydrogenation pathway of linoleic acid (LA) (18:2n-6). | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. | 0.501 |
Gamt | Nob1 | ENSRNOP00000036927 | ENSRNOP00000031905 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | 0.457 |
Gamt | Setd4 | ENSRNOP00000036927 | ENSRNOP00000002308 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | SET domain-containing 4. | 0.496 |
Gamt | Setd6 | ENSRNOP00000036927 | ENSRNOP00000016626 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. | 0.544 |
Nfkb2 | Rel | ENSRNOP00000026235 | ENSRNOP00000072332 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | REL proto-oncogene, NF-kB subunit. | 0.993 |
Nfkb2 | Rela | ENSRNOP00000026235 | ENSRNOP00000044552 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | 0.999 |
Nfkb2 | Relb | ENSRNOP00000026235 | ENSRNOP00000054614 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | RELB proto-oncogene, NF-kB subunit. | 0.999 |
Nfkb2 | Setd6 | ENSRNOP00000026235 | ENSRNOP00000016626 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. | 0.750 |
Nob1 | Gamt | ENSRNOP00000031905 | ENSRNOP00000036927 | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | 0.457 |
Nob1 | Setd6 | ENSRNOP00000031905 | ENSRNOP00000016626 | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. | 0.776 |
Polr3c | Setd6 | ENSRNOP00000028815 | ENSRNOP00000016626 | DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during i [...] | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. | 0.530 |
Rel | Nfkb2 | ENSRNOP00000072332 | ENSRNOP00000026235 | REL proto-oncogene, NF-kB subunit. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | 0.993 |
Rel | Rela | ENSRNOP00000072332 | ENSRNOP00000044552 | REL proto-oncogene, NF-kB subunit. | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | 0.993 |
Rel | Relb | ENSRNOP00000072332 | ENSRNOP00000054614 | REL proto-oncogene, NF-kB subunit. | RELB proto-oncogene, NF-kB subunit. | 0.993 |
Rel | Setd6 | ENSRNOP00000072332 | ENSRNOP00000016626 | REL proto-oncogene, NF-kB subunit. | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. | 0.527 |
Rela | Nfkb2 | ENSRNOP00000044552 | ENSRNOP00000026235 | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | 0.999 |
Rela | Rel | ENSRNOP00000044552 | ENSRNOP00000072332 | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | REL proto-oncogene, NF-kB subunit. | 0.993 |
Rela | Relb | ENSRNOP00000044552 | ENSRNOP00000054614 | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | RELB proto-oncogene, NF-kB subunit. | 0.999 |
Rela | Setd6 | ENSRNOP00000044552 | ENSRNOP00000016626 | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. | 0.953 |
Rela | Setd7 | ENSRNOP00000044552 | ENSRNOP00000017736 | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. | 0.530 |