node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agmat | Aoc1 | ENSRNOP00000016646 | ENSRNOP00000055909 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | 0.957 |
Agmat | Azin2 | ENSRNOP00000016646 | ENSRNOP00000072209 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Antizyme inhibitor 2; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the t [...] | 0.990 |
Agmat | Doxl1 | ENSRNOP00000016646 | ENSRNOP00000033821 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Amine oxidase. | 0.957 |
Agmat | Doxl2 | ENSRNOP00000016646 | ENSRNOP00000048618 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.957 |
Agmat | Oat | ENSRNOP00000016646 | ENSRNOP00000022628 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Ornithine aminotransferase, mitochondrial. | 0.937 |
Agmat | Odc1 | ENSRNOP00000016646 | ENSRNOP00000007259 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.986 |
Agmat | RGD1562036 | ENSRNOP00000016646 | ENSRNOP00000031505 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Similar to ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.985 |
Agmat | Sat1 | ENSRNOP00000016646 | ENSRNOP00000068531 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermidine/spermine N1-acetyl transferase 1. | 0.944 |
Agmat | Sat2 | ENSRNOP00000016646 | ENSRNOP00000015769 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermidine/spermine N1-acetyl transferase 2 (Predicted), isoform CRA_a. | 0.911 |
Agmat | Srm | ENSRNOP00000016646 | ENSRNOP00000014934 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.986 |
Aoc1 | Agmat | ENSRNOP00000055909 | ENSRNOP00000016646 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.957 |
Aoc1 | Azin2 | ENSRNOP00000055909 | ENSRNOP00000072209 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Antizyme inhibitor 2; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the t [...] | 0.596 |
Aoc1 | Doxl1 | ENSRNOP00000055909 | ENSRNOP00000033821 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase. | 0.904 |
Aoc1 | Doxl2 | ENSRNOP00000055909 | ENSRNOP00000048618 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.903 |
Aoc1 | Odc1 | ENSRNOP00000055909 | ENSRNOP00000007259 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.966 |
Aoc1 | RGD1562036 | ENSRNOP00000055909 | ENSRNOP00000031505 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Similar to ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.966 |
Aoc1 | Sat1 | ENSRNOP00000055909 | ENSRNOP00000068531 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Spermidine/spermine N1-acetyl transferase 1. | 0.921 |
Aoc1 | Sat2 | ENSRNOP00000055909 | ENSRNOP00000015769 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Spermidine/spermine N1-acetyl transferase 2 (Predicted), isoform CRA_a. | 0.903 |
Aoc1 | Srm | ENSRNOP00000055909 | ENSRNOP00000014934 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.935 |
Azin2 | Agmat | ENSRNOP00000072209 | ENSRNOP00000016646 | Antizyme inhibitor 2; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the t [...] | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.990 |