Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cd274 | Cd44 | ENSRNOP00000029992 | ENSRNOP00000009000 | Similar to PD-1-ligand (Predicted). | CD44 antigen. | 0.666 |
| Cd274 | Havcr2 | ENSRNOP00000029992 | ENSRNOP00000048351 | Similar to PD-1-ligand (Predicted). | Hepatitis A virus cellular receptor 2 homolog; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in [...] | 0.934 |
| Cd274 | Lag3 | ENSRNOP00000029992 | ENSRNOP00000036771 | Similar to PD-1-ligand (Predicted). | Secreted lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, act [...] | 0.863 |
| Cd274 | Lgals5 | ENSRNOP00000029992 | ENSRNOP00000016897 | Similar to PD-1-ligand (Predicted). | Galectin-5; May function in erythrocyte differentiation. | 0.616 |
| Cd274 | Lgals9 | ENSRNOP00000029992 | ENSRNOP00000017042 | Similar to PD-1-ligand (Predicted). | Galectin-9; Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma mem [...] | 0.680 |
| Cd274 | Pdcd1 | ENSRNOP00000029992 | ENSRNOP00000067189 | Similar to PD-1-ligand (Predicted). | Programmed cell death 1. | 0.993 |
| Cd274 | Pdcd1-2 | ENSRNOP00000029992 | ENSRNOP00000025743 | Similar to PD-1-ligand (Predicted). | Programmed cell death 1 (Predicted). | 0.999 |
| Cd274 | Pdcd1lg2 | ENSRNOP00000029992 | ENSRNOP00000021615 | Similar to PD-1-ligand (Predicted). | Programmed cell death 1 ligand 2. | 0.941 |
| Cd274 | Ptprc | ENSRNOP00000029992 | ENSRNOP00000063859 | Similar to PD-1-ligand (Predicted). | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). | 0.728 |
| Cd274 | Tigit | ENSRNOP00000029992 | ENSRNOP00000074881 | Similar to PD-1-ligand (Predicted). | T cell immunoreceptor with Ig and ITIM domains. | 0.836 |
| Cd44 | Cd274 | ENSRNOP00000009000 | ENSRNOP00000029992 | CD44 antigen. | Similar to PD-1-ligand (Predicted). | 0.666 |
| Cd44 | Havcr2 | ENSRNOP00000009000 | ENSRNOP00000048351 | CD44 antigen. | Hepatitis A virus cellular receptor 2 homolog; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in [...] | 0.635 |
| Cd44 | Lag3 | ENSRNOP00000009000 | ENSRNOP00000036771 | CD44 antigen. | Secreted lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, act [...] | 0.635 |
| Cd44 | Lgals5 | ENSRNOP00000009000 | ENSRNOP00000016897 | CD44 antigen. | Galectin-5; May function in erythrocyte differentiation. | 0.682 |
| Cd44 | Lgals9 | ENSRNOP00000009000 | ENSRNOP00000017042 | CD44 antigen. | Galectin-9; Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma mem [...] | 0.925 |
| Cd44 | Pdcd1 | ENSRNOP00000009000 | ENSRNOP00000067189 | CD44 antigen. | Programmed cell death 1. | 0.538 |
| Cd44 | Pdcd1-2 | ENSRNOP00000009000 | ENSRNOP00000025743 | CD44 antigen. | Programmed cell death 1 (Predicted). | 0.593 |
| Cd44 | Pdcd1lg2 | ENSRNOP00000009000 | ENSRNOP00000021615 | CD44 antigen. | Programmed cell death 1 ligand 2. | 0.411 |
| Cd44 | Ptprc | ENSRNOP00000009000 | ENSRNOP00000063859 | CD44 antigen. | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). | 0.926 |
| Cd44 | Tigit | ENSRNOP00000009000 | ENSRNOP00000074881 | CD44 antigen. | T cell immunoreceptor with Ig and ITIM domains. | 0.576 |
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