Fam89b protein (Rattus norvegicus) - STRING interaction network

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Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Anapc1	Anapc2	ENSRNOP00000052727	ENSRNOP00000015099	Anaphase promoting complex subunit 1 (Predicted).	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	0.999
Anapc1	Anapc4	ENSRNOP00000052727	ENSRNOP00000006093	Anaphase promoting complex subunit 1 (Predicted).	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.999
Anapc1	Anapc5	ENSRNOP00000052727	ENSRNOP00000001794	Anaphase promoting complex subunit 1 (Predicted).	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.999
Anapc1	Cdc16	ENSRNOP00000052727	ENSRNOP00000023736	Anaphase promoting complex subunit 1 (Predicted).	CDC16 cell division cycle 16 homolog (S. cerevisiae).	0.999
Anapc1	Cdc23	ENSRNOP00000052727	ENSRNOP00000035675	Anaphase promoting complex subunit 1 (Predicted).	CDC23 (Cell division cycle 23, yeast, homolog), isoform CRA_b.	0.999
Anapc1	Cdc27	ENSRNOP00000052727	ENSRNOP00000007963	Anaphase promoting complex subunit 1 (Predicted).	Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.999
Anapc1	Fam89b	ENSRNOP00000052727	ENSRNOP00000016987	Anaphase promoting complex subunit 1 (Predicted).	Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family.	0.788
Anapc2	Anapc1	ENSRNOP00000015099	ENSRNOP00000052727	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	Anaphase promoting complex subunit 1 (Predicted).	0.999
Anapc2	Anapc4	ENSRNOP00000015099	ENSRNOP00000006093	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.999
Anapc2	Anapc5	ENSRNOP00000015099	ENSRNOP00000001794	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.999
Anapc2	Cdc16	ENSRNOP00000015099	ENSRNOP00000023736	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	CDC16 cell division cycle 16 homolog (S. cerevisiae).	0.999
Anapc2	Cdc23	ENSRNOP00000015099	ENSRNOP00000035675	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	CDC23 (Cell division cycle 23, yeast, homolog), isoform CRA_b.	0.999
Anapc2	Cdc27	ENSRNOP00000015099	ENSRNOP00000007963	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.999
Anapc2	Fam89b	ENSRNOP00000015099	ENSRNOP00000016987	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family.	0.788
Anapc4	Anapc1	ENSRNOP00000006093	ENSRNOP00000052727	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Anaphase promoting complex subunit 1 (Predicted).	0.999
Anapc4	Anapc2	ENSRNOP00000006093	ENSRNOP00000015099	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	0.999
Anapc4	Anapc5	ENSRNOP00000006093	ENSRNOP00000001794	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.999
Anapc4	Cdc16	ENSRNOP00000006093	ENSRNOP00000023736	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	CDC16 cell division cycle 16 homolog (S. cerevisiae).	0.998
Anapc4	Cdc23	ENSRNOP00000006093	ENSRNOP00000035675	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	CDC23 (Cell division cycle 23, yeast, homolog), isoform CRA_b.	0.999
Anapc4	Cdc27	ENSRNOP00000006093	ENSRNOP00000007963	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.998

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