node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adamts6 | B3glct | ENSRNOP00000016997 | ENSRNOP00000069223 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Beta 3-glucosyltransferase. | 0.457 |
Adamts6 | Comp | ENSRNOP00000016997 | ENSRNOP00000067037 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] | 0.476 |
Adamts6 | Fam196b | ENSRNOP00000016997 | ENSRNOP00000049022 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Uncharacterized protein. | 0.424 |
Adamts6 | Fbn1 | ENSRNOP00000016997 | ENSRNOP00000052876 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Fibrillin 1, isoform CRA_a. | 0.606 |
Adamts6 | Furin | ENSRNOP00000016997 | ENSRNOP00000015521 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. | 0.415 |
Adamts6 | Ltbp1 | ENSRNOP00000016997 | ENSRNOP00000040099 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. | 0.593 |
Adamts6 | Pofut2 | ENSRNOP00000016997 | ENSRNOP00000001644 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Protein O-fucosyltransferase 2 (Predicted), isoform CRA_a. | 0.461 |
Adamts6 | Ppwd1 | ENSRNOP00000016997 | ENSRNOP00000016863 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Peptidylprolyl isomerase domain and WD repeat containing 1 (Predicted). | 0.552 |
Adamts6 | Rnf180 | ENSRNOP00000016997 | ENSRNOP00000059648 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Ring finger protein 180. | 0.412 |
Adamts6 | Srek1ip1 | ENSRNOP00000016997 | ENSRNOP00000064069 | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.473 |
B3glct | Adamts6 | ENSRNOP00000069223 | ENSRNOP00000016997 | Beta 3-glucosyltransferase. | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | 0.457 |
B3glct | Pofut2 | ENSRNOP00000069223 | ENSRNOP00000001644 | Beta 3-glucosyltransferase. | Protein O-fucosyltransferase 2 (Predicted), isoform CRA_a. | 0.827 |
Comp | Adamts6 | ENSRNOP00000067037 | ENSRNOP00000016997 | Cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | 0.476 |
Fam196b | Adamts6 | ENSRNOP00000049022 | ENSRNOP00000016997 | Uncharacterized protein. | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | 0.424 |
Fbn1 | Adamts6 | ENSRNOP00000052876 | ENSRNOP00000016997 | Fibrillin 1, isoform CRA_a. | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | 0.606 |
Fbn1 | Furin | ENSRNOP00000052876 | ENSRNOP00000015521 | Fibrillin 1, isoform CRA_a. | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. | 0.841 |
Fbn1 | Ltbp1 | ENSRNOP00000052876 | ENSRNOP00000040099 | Fibrillin 1, isoform CRA_a. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. | 0.971 |
Furin | Adamts6 | ENSRNOP00000015521 | ENSRNOP00000016997 | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | 0.415 |
Furin | Fbn1 | ENSRNOP00000015521 | ENSRNOP00000052876 | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. | Fibrillin 1, isoform CRA_a. | 0.841 |
Ltbp1 | Adamts6 | ENSRNOP00000040099 | ENSRNOP00000016997 | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. | ADAM metallopeptidase with thrombospondin type 1 motif, 6. | 0.593 |