Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DctdDeoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. (184 aa)    
Predicted Functional Partners:
Tyms
Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
  
 
 0.966
Dck
Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA).
   
 0.963
Dctpp1
dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
   
 0.959
Nt5c2
5'-nucleotidase, cytosolic II.
     
 0.949
Tk1
Thymidine kinase, cytosolic; Belongs to the thymidine kinase family.
  
 
 0.943
Tk2
Thymidine kinase 2, mitochondrial (Predicted).
   
 0.941
Dtymk
Deoxythymidylate kinase (Predicted), isoform CRA_b.
    
 0.930
Nt5c
5', 3'-nucleotidase, cytosolic.
     
 0.912
Cmpk2
Cytidine/uridine monophosphate kinase 2.
    
 0.912
Cmpk1
UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
     
 0.910
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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