STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Spink1Serine protease inhibitor Kazal-type 1-like; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). (79 aa)    
Predicted Functional Partners:
Ctrc
Chymotrypsin-C; Has chymotrypsin-type protease activity and hypocalcemic activity.
   
 
 0.761
Prss1
Anionic trypsin-1; Belongs to the peptidase S1 family.
   
 
 0.721
Cela1
Chymotrypsin-like elastase family member 1; Acts upon elastin.
   
 
 0.579
Prss2
Anionic trypsin-2; Belongs to the peptidase S1 family.
   
 
 0.577
Cpa1
Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
   
  
 0.575
Cela3b
Elastase 3B, pancreatic (Predicted), isoform CRA_b; Belongs to the peptidase S1 family.
   
 
 0.510
Spink13
Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction.
      
 0.492
RGD1564865
Similar to 20-alpha-hydroxysteroid dehydrogenase.
   
  
 0.489
Spink4
Serine peptidase inhibitor, Kazal type 4.
      
 0.475
Msmb
Beta-microseminoprotein; Belongs to the beta-microseminoprotein family.
   
  
 0.460
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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