node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actl6a | Actr5 | ENSRNOP00000015460 | ENSRNOP00000036100 | Actin-like 6A; Belongs to the actin family. | Actin-related protein 5; Belongs to the actin family. | 0.956 |
Actl6a | Actr8 | ENSRNOP00000015460 | ENSRNOP00000020750 | Actin-like 6A; Belongs to the actin family. | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. | 0.968 |
Actl6a | Dmap1 | ENSRNOP00000015460 | ENSRNOP00000026336 | Actin-like 6A; Belongs to the actin family. | DNA methyltransferase 1-associated protein 1. | 0.982 |
Actl6a | Ruvbl1 | ENSRNOP00000015460 | ENSRNOP00000075190 | Actin-like 6A; Belongs to the actin family. | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] | 0.976 |
Actl6a | Ruvbl2 | ENSRNOP00000015460 | ENSRNOP00000028217 | Actin-like 6A; Belongs to the actin family. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.984 |
Actl6a | Vps72 | ENSRNOP00000015460 | ENSRNOP00000028625 | Actin-like 6A; Belongs to the actin family. | Vacuolar protein sorting 72 homolog (S. cerevisiae). | 0.938 |
Actr5 | Actl6a | ENSRNOP00000036100 | ENSRNOP00000015460 | Actin-related protein 5; Belongs to the actin family. | Actin-like 6A; Belongs to the actin family. | 0.956 |
Actr5 | Actr8 | ENSRNOP00000036100 | ENSRNOP00000020750 | Actin-related protein 5; Belongs to the actin family. | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. | 0.982 |
Actr5 | Dmap1 | ENSRNOP00000036100 | ENSRNOP00000026336 | Actin-related protein 5; Belongs to the actin family. | DNA methyltransferase 1-associated protein 1. | 0.549 |
Actr5 | Rpap3 | ENSRNOP00000036100 | ENSRNOP00000074251 | Actin-related protein 5; Belongs to the actin family. | RNA polymerase II-associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Belongs to the RPAP3 family. | 0.757 |
Actr5 | Ruvbl1 | ENSRNOP00000036100 | ENSRNOP00000075190 | Actin-related protein 5; Belongs to the actin family. | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] | 0.977 |
Actr5 | Ruvbl2 | ENSRNOP00000036100 | ENSRNOP00000028217 | Actin-related protein 5; Belongs to the actin family. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.992 |
Actr8 | Actl6a | ENSRNOP00000020750 | ENSRNOP00000015460 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. | Actin-like 6A; Belongs to the actin family. | 0.968 |
Actr8 | Actr5 | ENSRNOP00000020750 | ENSRNOP00000036100 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. | Actin-related protein 5; Belongs to the actin family. | 0.982 |
Actr8 | Dmap1 | ENSRNOP00000020750 | ENSRNOP00000026336 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. | DNA methyltransferase 1-associated protein 1. | 0.779 |
Actr8 | Ruvbl1 | ENSRNOP00000020750 | ENSRNOP00000075190 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] | 0.973 |
Actr8 | Ruvbl2 | ENSRNOP00000020750 | ENSRNOP00000028217 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.974 |
Ctnnb1 | Ruvbl1 | ENSRNOP00000068620 | ENSRNOP00000075190 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] | 0.985 |
Ctnnb1 | Ruvbl2 | ENSRNOP00000068620 | ENSRNOP00000028217 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.791 |
Dmap1 | Actl6a | ENSRNOP00000026336 | ENSRNOP00000015460 | DNA methyltransferase 1-associated protein 1. | Actin-like 6A; Belongs to the actin family. | 0.982 |