node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldh18a1 | Cad | ENSRNOP00000020940 | ENSRNOP00000030030 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.746 |
Aldh18a1 | Cps1 | ENSRNOP00000020940 | ENSRNOP00000019021 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | 0.747 |
Aldh18a1 | Gad1 | ENSRNOP00000020940 | ENSRNOP00000072778 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. | 0.865 |
Aldh18a1 | Gad2 | ENSRNOP00000020940 | ENSRNOP00000024901 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.867 |
Aldh18a1 | Gfpt1 | ENSRNOP00000020940 | ENSRNOP00000075660 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. | 0.495 |
Aldh18a1 | Gfpt2 | ENSRNOP00000020940 | ENSRNOP00000003770 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. | 0.538 |
Aldh18a1 | Gls2 | ENSRNOP00000020940 | ENSRNOP00000018737 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Belongs to the glutaminase family. | 0.956 |
Aldh18a1 | Glud1 | ENSRNOP00000020940 | ENSRNOP00000075032 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. | 0.996 |
Aldh18a1 | Glul | ENSRNOP00000020940 | ENSRNOP00000065890 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | 0.928 |
Aldh18a1 | Ppat | ENSRNOP00000020940 | ENSRNOP00000002905 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Amidophosphoribosyltransferase. | 0.562 |
Cad | Aldh18a1 | ENSRNOP00000030030 | ENSRNOP00000020940 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.746 |
Cad | Cps1 | ENSRNOP00000030030 | ENSRNOP00000019021 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | 0.905 |
Cad | Gad1 | ENSRNOP00000030030 | ENSRNOP00000072778 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. | 0.834 |
Cad | Gad2 | ENSRNOP00000030030 | ENSRNOP00000024901 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.834 |
Cad | Gfpt1 | ENSRNOP00000030030 | ENSRNOP00000075660 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. | 0.927 |
Cad | Gfpt2 | ENSRNOP00000030030 | ENSRNOP00000003770 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. | 0.936 |
Cad | Gls2 | ENSRNOP00000030030 | ENSRNOP00000018737 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Belongs to the glutaminase family. | 0.906 |
Cad | Glud1 | ENSRNOP00000030030 | ENSRNOP00000075032 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. | 0.734 |
Cad | Glul | ENSRNOP00000030030 | ENSRNOP00000065890 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | 0.953 |
Cad | Ppat | ENSRNOP00000030030 | ENSRNOP00000002905 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Amidophosphoribosyltransferase. | 0.984 |