node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cyba | Cybb | ENSRNOP00000017564 | ENSRNOP00000031063 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Cytochrome b-245, beta polypeptide, isoform CRA_a. | 0.999 |
Cyba | Duox1 | ENSRNOP00000017564 | ENSRNOP00000045928 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. | 0.971 |
Cyba | Ncf1 | ENSRNOP00000017564 | ENSRNOP00000002028 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Neutrophil cytosolic factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). | 0.999 |
Cyba | Ncf4 | ENSRNOP00000017564 | ENSRNOP00000009544 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Similar to neutrophil cytosolic factor 4, isoform CRA_a. | 0.997 |
Cyba | Nox1 | ENSRNOP00000017564 | ENSRNOP00000065995 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | NADPH oxidase 1; Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism. | 0.999 |
Cyba | Nox3 | ENSRNOP00000017564 | ENSRNOP00000022148 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity). | 0.998 |
Cyba | Nox4 | ENSRNOP00000017564 | ENSRNOP00000018990 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. | 0.999 |
Cyba | Noxa1 | ENSRNOP00000017564 | ENSRNOP00000012375 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3 (By similarity). | 0.999 |
Cyba | Noxo1 | ENSRNOP00000017564 | ENSRNOP00000033263 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | NADPH oxidase organizer 1 (Predicted). | 0.999 |
Cyba | Tlr4 | ENSRNOP00000017564 | ENSRNOP00000014020 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.459 |
Cybb | Cyba | ENSRNOP00000031063 | ENSRNOP00000017564 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | 0.999 |
Cybb | Duox1 | ENSRNOP00000031063 | ENSRNOP00000045928 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. | 0.969 |
Cybb | Ncf1 | ENSRNOP00000031063 | ENSRNOP00000002028 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Neutrophil cytosolic factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). | 0.999 |
Cybb | Ncf4 | ENSRNOP00000031063 | ENSRNOP00000009544 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Similar to neutrophil cytosolic factor 4, isoform CRA_a. | 0.996 |
Cybb | Nox1 | ENSRNOP00000031063 | ENSRNOP00000065995 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | NADPH oxidase 1; Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism. | 0.998 |
Cybb | Nox3 | ENSRNOP00000031063 | ENSRNOP00000022148 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity). | 0.993 |
Cybb | Nox4 | ENSRNOP00000031063 | ENSRNOP00000018990 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. | 0.998 |
Cybb | Noxa1 | ENSRNOP00000031063 | ENSRNOP00000012375 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3 (By similarity). | 0.955 |
Cybb | Noxo1 | ENSRNOP00000031063 | ENSRNOP00000033263 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | NADPH oxidase organizer 1 (Predicted). | 0.966 |
Cybb | Tlr4 | ENSRNOP00000031063 | ENSRNOP00000014020 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.875 |