| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Asl | Ass1 | ENSRNOP00000001211 | ENSRNOP00000076301 | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.999 |
| Asl | Cps1 | ENSRNOP00000001211 | ENSRNOP00000019021 | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | 0.941 |
| Asl | Gls2 | ENSRNOP00000001211 | ENSRNOP00000018737 | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Belongs to the glutaminase family. | 0.527 |
| Asl | Glud1 | ENSRNOP00000001211 | ENSRNOP00000075032 | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. | 0.740 |
| Asl | Glul | ENSRNOP00000001211 | ENSRNOP00000065890 | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | 0.546 |
| Asl | Nags | ENSRNOP00000001211 | ENSRNOP00000028332 | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | N-acetylglutamate synthase (Predicted), isoform CRA_a. | 0.994 |
| Asl | Otc | ENSRNOP00000001211 | ENSRNOP00000004686 | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.957 |
| Asl | Ppat | ENSRNOP00000001211 | ENSRNOP00000002905 | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | Amidophosphoribosyltransferase. | 0.417 |
| Ass1 | Asl | ENSRNOP00000076301 | ENSRNOP00000001211 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | 0.999 |
| Ass1 | Cps1 | ENSRNOP00000076301 | ENSRNOP00000019021 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | 0.996 |
| Ass1 | Gls2 | ENSRNOP00000076301 | ENSRNOP00000018737 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Belongs to the glutaminase family. | 0.635 |
| Ass1 | Glud1 | ENSRNOP00000076301 | ENSRNOP00000075032 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. | 0.616 |
| Ass1 | Glul | ENSRNOP00000076301 | ENSRNOP00000065890 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | 0.683 |
| Ass1 | Nags | ENSRNOP00000076301 | ENSRNOP00000028332 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | N-acetylglutamate synthase (Predicted), isoform CRA_a. | 0.971 |
| Ass1 | Otc | ENSRNOP00000076301 | ENSRNOP00000004686 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.998 |
| Ass1 | Ppat | ENSRNOP00000076301 | ENSRNOP00000002905 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Amidophosphoribosyltransferase. | 0.631 |
| Cps1 | Asl | ENSRNOP00000019021 | ENSRNOP00000001211 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | 0.941 |
| Cps1 | Ass1 | ENSRNOP00000019021 | ENSRNOP00000076301 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.996 |
| Cps1 | Dhodh | ENSRNOP00000019021 | ENSRNOP00000061315 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 0.931 |
| Cps1 | Gls2 | ENSRNOP00000019021 | ENSRNOP00000018737 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Belongs to the glutaminase family. | 0.928 |
