| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Adgra2 | Cldn5 | ENSRNOP00000017776 | ENSRNOP00000064048 | Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | 0.578 |
| Adgra2 | Mfsd2a | ENSRNOP00000017776 | ENSRNOP00000019080 | Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. | Major facilitator superfamily domain-containing 2A. | 0.545 |
| Cav1 | Cldn5 | ENSRNOP00000073712 | ENSRNOP00000064048 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | 0.697 |
| Cav1 | Mfsd2a | ENSRNOP00000073712 | ENSRNOP00000019080 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Major facilitator superfamily domain-containing 2A. | 0.664 |
| Cav1 | Ocln | ENSRNOP00000073712 | ENSRNOP00000024674 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells. Belongs to the ELL/occludin family. | 0.664 |
| Cav1 | Plvap | ENSRNOP00000073712 | ENSRNOP00000023927 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Plasmalemma vesicle-associated protein; Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. | 0.583 |
| Cav1 | Tjp1 | ENSRNOP00000073712 | ENSRNOP00000072324 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Tight junction protein ZO-1; TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role [...] | 0.605 |
| Cldn5 | Adgra2 | ENSRNOP00000064048 | ENSRNOP00000017776 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. | 0.578 |
| Cldn5 | Cav1 | ENSRNOP00000064048 | ENSRNOP00000073712 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | 0.697 |
| Cldn5 | Mfsd2a | ENSRNOP00000064048 | ENSRNOP00000019080 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Major facilitator superfamily domain-containing 2A. | 0.800 |
| Cldn5 | Ocln | ENSRNOP00000064048 | ENSRNOP00000024674 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells. Belongs to the ELL/occludin family. | 0.992 |
| Cldn5 | Plvap | ENSRNOP00000064048 | ENSRNOP00000023927 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Plasmalemma vesicle-associated protein; Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. | 0.732 |
| Cldn5 | Slc2a1 | ENSRNOP00000064048 | ENSRNOP00000061340 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). | 0.525 |
| Cldn5 | Slc7a5 | ENSRNOP00000064048 | ENSRNOP00000025784 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Large neutral amino acids transporter small subunit 1; The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. Functions as an amino acid exchanger (By similarity). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (By similarity). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (Pr [...] | 0.401 |
| Cldn5 | Tjp1 | ENSRNOP00000064048 | ENSRNOP00000072324 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Tight junction protein ZO-1; TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role [...] | 0.994 |
| Mfsd2a | Adgra2 | ENSRNOP00000019080 | ENSRNOP00000017776 | Major facilitator superfamily domain-containing 2A. | Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. | 0.545 |
| Mfsd2a | Cav1 | ENSRNOP00000019080 | ENSRNOP00000073712 | Major facilitator superfamily domain-containing 2A. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | 0.664 |
| Mfsd2a | Cldn5 | ENSRNOP00000019080 | ENSRNOP00000064048 | Major facilitator superfamily domain-containing 2A. | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | 0.800 |
| Mfsd2a | Ocln | ENSRNOP00000019080 | ENSRNOP00000024674 | Major facilitator superfamily domain-containing 2A. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells. Belongs to the ELL/occludin family. | 0.716 |
| Mfsd2a | Plvap | ENSRNOP00000019080 | ENSRNOP00000023927 | Major facilitator superfamily domain-containing 2A. | Plasmalemma vesicle-associated protein; Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. | 0.658 |
