STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZgpatZinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). (507 aa)    
Predicted Functional Partners:
Zfyve19
Similar to Zinc finger, FYVE domain containing 19.
   
  
 0.745
Zfand2b
AN1-type zinc finger protein 2B; Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism tha [...]
   
  
 0.732
Nt5c
5', 3'-nucleotidase, cytosolic.
      
 0.704
Prpf3
Pre-mRNA-processing factor 3.
   
   0.649
Amer2
APC membrane recruitment protein 2.
   
  
 0.643
Lrch4
Leucine-rich repeats and calponin homology domain-containing 4.
   
  
 0.638
E4f1
E4F transcription factor 1.
   
   0.571
Zfp637
RCG30169, isoform CRA_b.
   
  
 0.568
Marchf6
Membrane associated ring-CH-type finger 6.
   
  
 0.567
Prpf4
PRP4 pre-mRNA processing factor 4 homolog (Yeast).
   
   0.514
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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