Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cars | Hsbp1 | ENSRNOP00000050342 | ENSRNOP00000019443 | Cysteinyl-tRNA synthetase (Predicted), isoform CRA_b. | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | 0.484 |
| Cars | Ireb2 | ENSRNOP00000050342 | ENSRNOP00000070223 | Cysteinyl-tRNA synthetase (Predicted), isoform CRA_b. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA; Belongs to the aconitase/IPM isomerase family. | 0.530 |
| Cars | Lpcat3 | ENSRNOP00000050342 | ENSRNOP00000017090 | Cysteinyl-tRNA synthetase (Predicted), isoform CRA_b. | Lysophospholipid acyltransferase 5; Seems to be the major enzyme contributing to lysophosphatidylcholine acyltransferase activity in the liver. Favors unsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Displays lysophosphatidylserine acyltransferase (LPSAT) activity (By similarity). | 0.594 |
| Hsbp1 | Cars | ENSRNOP00000019443 | ENSRNOP00000050342 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | Cysteinyl-tRNA synthetase (Predicted), isoform CRA_b. | 0.484 |
| Hsbp1 | Hsf1 | ENSRNOP00000019443 | ENSRNOP00000047030 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | Heat shock transcription factor 1. | 0.869 |
| Hsbp1 | Hspa4 | ENSRNOP00000019443 | ENSRNOP00000023628 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.509 |
| Hsbp1 | Hsph1 | ENSRNOP00000019443 | ENSRNOP00000001201 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.480 |
| Hsbp1 | Ireb2 | ENSRNOP00000019443 | ENSRNOP00000070223 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA; Belongs to the aconitase/IPM isomerase family. | 0.637 |
| Hsbp1 | LOC680121 | ENSRNOP00000019443 | ENSRNOP00000058593 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.534 |
| Hsbp1 | Lpcat3 | ENSRNOP00000019443 | ENSRNOP00000017090 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | Lysophospholipid acyltransferase 5; Seems to be the major enzyme contributing to lysophosphatidylcholine acyltransferase activity in the liver. Favors unsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Displays lysophosphatidylserine acyltransferase (LPSAT) activity (By similarity). | 0.551 |
| Hsbp1 | Rbx1 | ENSRNOP00000019443 | ENSRNOP00000069049 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | Ring-box 1. | 0.830 |
| Hsbp1 | Stoml2 | ENSRNOP00000019443 | ENSRNOP00000013151 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | Stomatin-like protein 2, mitochondrial; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. M [...] | 0.502 |
| Hsbp1 | Washc3 | ENSRNOP00000019443 | ENSRNOP00000006903 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | RCG48807, isoform CRA_a. | 0.815 |
| Hsf1 | Hsbp1 | ENSRNOP00000047030 | ENSRNOP00000019443 | Heat shock transcription factor 1. | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | 0.869 |
| Hsf1 | Hspa4 | ENSRNOP00000047030 | ENSRNOP00000023628 | Heat shock transcription factor 1. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.934 |
| Hsf1 | Hsph1 | ENSRNOP00000047030 | ENSRNOP00000001201 | Heat shock transcription factor 1. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.610 |
| Hsf1 | LOC680121 | ENSRNOP00000047030 | ENSRNOP00000058593 | Heat shock transcription factor 1. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.941 |
| Hspa4 | Hsbp1 | ENSRNOP00000023628 | ENSRNOP00000019443 | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). | 0.509 |
| Hspa4 | Hsf1 | ENSRNOP00000023628 | ENSRNOP00000047030 | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | Heat shock transcription factor 1. | 0.934 |
| Hspa4 | Hsph1 | ENSRNOP00000023628 | ENSRNOP00000001201 | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.797 |
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