STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyhr1Cysteine and histidine-rich protein 1. (272 aa)    
Predicted Functional Partners:
Kansl1
KAT8 regulatory NSL complex subunit 1.
      
 0.741
Zc3h3
Zinc finger CCCH type-containing 3.
      
 0.669
Cpsf1
Cleavage and polyadenylation-specific factor 1.
   
 
 0.643
Mroh1
Maestro heat-like repeat family member 1.
   
  
 0.600
Maf1
Repressor of RNA polymerase III transcription MAF1 homolog; Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity). Plays also a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to t [...]
   
  
 0.594
Sharpin
Sharpin; Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BI [...]
   
  
 0.586
Grina
Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily.
   
  
 0.568
Exosc4
Exosome component 4.
   
  
 0.563
MGC94199
Protein C8orf37 homolog; May be involved in photoreceptor outer segment disk morphogenesis (By similarity).
      
 0.559
MGC94199-2
Similar to RIKEN cDNA 2610301B20; EST AI428449.
      
 0.559
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.