Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Srfbp1Serum response factor-binding protein 1; May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). (442 aa)    
Predicted Functional Partners:
Tbl3
Transducin beta-like protein 3.
   
  0.953
Heatr1
HEAT repeat-containing protein 1.
   
  0.947
Utp20
UTP20 small subunit processome component.
   
 0.939
Bysl
Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
   
 
 0.929
Kri1
KRI1 homolog.
   
  0.928
Ddx10
RNA helicase.
   
 
 0.917
Rrp36
Ribosomal RNA-processing 36.
   
 
  0.913
Nop9
Similar to chromosome 14 open reading frame 21 (Predicted).
   
  0.910
Imp4
U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).
   
  0.907
Mphosph10
U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family.
   
  0.866
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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