Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HpHaptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] (346 aa)    
Predicted Functional Partners:
Hba-a1
Hemoglobin alpha, adult chain 3; Belongs to the globin family.
   
 0.997
Hbz
Hemoglobin subunit zeta; Belongs to the globin family.
    
 0.992
Hbb
Hemoglobin subunit beta-1; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.
   
 0.986
LOC103694857
Hemoglobin subunit beta-2; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.
   
 0.985
Hba1
Hemoglobin subunit alpha-1/2; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.
    
 0.983
Hpx
Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
   
 
 0.947
Serpina1
Alpha-1-antiproteinase; Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin; Belongs to the serpin family.
   
 0.947
Orm1
Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family.
   
 
 0.936
Cd163
CD163 antigen (Predicted).
   
 0.925
Hbe2
Hemoglobin, epsilon 2; Belongs to the globin family.
   
 0.924
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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