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Gsr protein (Rattus norvegicus) - STRING interaction network
"Gsr" - Glutathione reductase in Rattus norvegicus
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GsrGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family (410 aa)    
Predicted Functional Partners:
Cat
Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family (527 aa)
     
 
  0.989
Gss
Glutathione synthetase; Belongs to the eukaryotic GSH synthase family (474 aa)
     
 
  0.973
Txn1
Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (104 aa)
   
 
  0.972
Hpgds
Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide; Belongs to the GST superfamily. Sigma family (199 aa)
     
 
  0.964
Gstm4
Glutathione S-transferase mu 4 (218 aa)
     
 
  0.964
Gstm3
Glutathione S-transferase mu 3 (218 aa)
     
 
  0.964
Gstm6
Glutathione S-transferase, mu 6 (218 aa)
     
 
  0.964
G6pd
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity); Belongs to the glucose-6-phosphate dehydrogenase family (515 aa)
   
   
  0.961
Gpx7
Glutathione peroxidase 7; Belongs to the glutathione peroxidase family (186 aa)
   
   
  0.950
Ggt7
Glutathione hydrolase 7; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family (662 aa)
       
  0.932
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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