| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Anapc11 | Anapc2 | ENSRNOP00000051837 | ENSRNOP00000015099 | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | 0.999 |
| Anapc11 | Ccnb1 | ENSRNOP00000051837 | ENSRNOP00000075114 | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | 0.903 |
| Anapc11 | Cdc20 | ENSRNOP00000051837 | ENSRNOP00000037772 | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] | 0.998 |
| Anapc11 | Cdk1 | ENSRNOP00000051837 | ENSRNOP00000070138 | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.743 |
| Anapc11 | Fzr1 | ENSRNOP00000051837 | ENSRNOP00000005624 | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. | Fizzy/cell division cycle 20 related 1 (Drosophila) (Predicted), isoform CRA_a. | 0.998 |
| Anapc11 | Ube2c | ENSRNOP00000051837 | ENSRNOP00000020323 | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. | Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. | 0.993 |
| Anapc11 | Ube2s | ENSRNOP00000051837 | ENSRNOP00000022977 | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. | Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] | 0.993 |
| Anapc2 | Anapc11 | ENSRNOP00000015099 | ENSRNOP00000051837 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. | 0.999 |
| Anapc2 | Aurka | ENSRNOP00000015099 | ENSRNOP00000051977 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for ini [...] | 0.570 |
| Anapc2 | Ccna2 | ENSRNOP00000015099 | ENSRNOP00000021156 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | Cyclin A2, isoform CRA_b. | 0.561 |
| Anapc2 | Ccnb1 | ENSRNOP00000015099 | ENSRNOP00000075114 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | 0.975 |
| Anapc2 | Cdc20 | ENSRNOP00000015099 | ENSRNOP00000037772 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] | 0.999 |
| Anapc2 | Cdk1 | ENSRNOP00000015099 | ENSRNOP00000070138 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.868 |
| Anapc2 | Fzr1 | ENSRNOP00000015099 | ENSRNOP00000005624 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | Fizzy/cell division cycle 20 related 1 (Drosophila) (Predicted), isoform CRA_a. | 0.999 |
| Anapc2 | Ube2c | ENSRNOP00000015099 | ENSRNOP00000020323 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. | 0.991 |
| Anapc2 | Ube2s | ENSRNOP00000015099 | ENSRNOP00000022977 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] | 0.986 |
| Aurka | Anapc2 | ENSRNOP00000051977 | ENSRNOP00000015099 | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for ini [...] | Anaphase-promoting complex subunit 2; Belongs to the cullin family. | 0.570 |
| Aurka | Birc5 | ENSRNOP00000051977 | ENSRNOP00000065784 | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for ini [...] | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | 0.998 |
| Aurka | Ccna2 | ENSRNOP00000051977 | ENSRNOP00000021156 | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for ini [...] | Cyclin A2, isoform CRA_b. | 0.951 |
| Aurka | Ccnb1 | ENSRNOP00000051977 | ENSRNOP00000075114 | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for ini [...] | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | 0.981 |
