Timm21 protein (Rattus norvegicus) - STRING interaction network

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Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dnajc15	Grpel1	ENSRNOP00000012530	ENSRNOP00000070967	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	0.960
Dnajc15	LOC100911130	ENSRNOP00000012530	ENSRNOP00000038100	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.789
Dnajc15	Pam16	ENSRNOP00000012530	ENSRNOP00000006314	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	Mitochondrial import inner membrane translocase subunit TIM16; Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity (By similarity); Belongs to the TIM16/PAM16 family.	0.994
Dnajc15	Romo1	ENSRNOP00000012530	ENSRNOP00000026856	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	Reactive oxygen species modulator 1-like.	0.772
Dnajc15	Timm17a	ENSRNOP00000012530	ENSRNOP00000009398	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	Mitochondrial import inner membrane translocase subunit Tim17-A; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.872
Dnajc15	Timm21	ENSRNOP00000012530	ENSRNOP00000020376	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.	0.884
Dnajc15	Timm23	ENSRNOP00000012530	ENSRNOP00000026932	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	Mitochondrial import inner membrane translocase subunit Tim23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.868
Dnajc15	Timm44	ENSRNOP00000012530	ENSRNOP00000001409	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.	0.893
Dnajc15	Timm50	ENSRNOP00000012530	ENSRNOP00000053926	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.678
Dnajc15	Tomm22	ENSRNOP00000012530	ENSRNOP00000019323	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases ; Belongs to the Tom22 family.	0.630
Grpel1	Dnajc15	ENSRNOP00000070967	ENSRNOP00000012530	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.	0.960
Grpel1	LOC100911130	ENSRNOP00000070967	ENSRNOP00000038100	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.792
Grpel1	Pam16	ENSRNOP00000070967	ENSRNOP00000006314	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	Mitochondrial import inner membrane translocase subunit TIM16; Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity (By similarity); Belongs to the TIM16/PAM16 family.	0.979
Grpel1	Romo1	ENSRNOP00000070967	ENSRNOP00000026856	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	Reactive oxygen species modulator 1-like.	0.731
Grpel1	Timm17a	ENSRNOP00000070967	ENSRNOP00000009398	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	Mitochondrial import inner membrane translocase subunit Tim17-A; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.932
Grpel1	Timm21	ENSRNOP00000070967	ENSRNOP00000020376	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.	0.836
Grpel1	Timm23	ENSRNOP00000070967	ENSRNOP00000026932	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	Mitochondrial import inner membrane translocase subunit Tim23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.833
Grpel1	Timm44	ENSRNOP00000070967	ENSRNOP00000001409	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.	0.972
Grpel1	Timm50	ENSRNOP00000070967	ENSRNOP00000053926	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.609
Grpel1	Tomm22	ENSRNOP00000070967	ENSRNOP00000019323	GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family.	Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases ; Belongs to the Tom22 family.	0.445

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