node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D4A7L5_RAT | Kctd2 | ENSRNOP00000047101 | ENSRNOP00000059246 | Small ubiquitin-related modifier. | Potassium channel tetramerization domain-containing 2. | 0.623 |
D4A7L5_RAT | LOC102553386 | ENSRNOP00000047101 | ENSRNOP00000075659 | Small ubiquitin-related modifier. | SUMO-conjugating enzyme UBC9-like. | 0.653 |
D4A7L5_RAT | Sae1 | ENSRNOP00000047101 | ENSRNOP00000020402 | Small ubiquitin-related modifier. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.941 |
D4A7L5_RAT | Senp1 | ENSRNOP00000047101 | ENSRNOP00000031127 | Small ubiquitin-related modifier. | SUMO-specific peptidase 1. | 0.910 |
D4A7L5_RAT | Sumo1 | ENSRNOP00000047101 | ENSRNOP00000022048 | Small ubiquitin-related modifier. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.438 |
D4A7L5_RAT | Uba2 | ENSRNOP00000047101 | ENSRNOP00000028672 | Small ubiquitin-related modifier. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.914 |
D4A7L5_RAT | Ube2i | ENSRNOP00000047101 | ENSRNOP00000024406 | Small ubiquitin-related modifier. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451 (By similarity). Can catalyze the formation of poly-SUMO chains (By similarity). Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386' (By similarity). Mediates sumoylation of ERCC6 which is essential for its transcription-coupled [...] | 0.867 |
Kctd2 | D4A7L5_RAT | ENSRNOP00000059246 | ENSRNOP00000047101 | Potassium channel tetramerization domain-containing 2. | Small ubiquitin-related modifier. | 0.623 |
Kctd2 | Sae1 | ENSRNOP00000059246 | ENSRNOP00000020402 | Potassium channel tetramerization domain-containing 2. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.831 |
Kctd2 | Sumo1 | ENSRNOP00000059246 | ENSRNOP00000022048 | Potassium channel tetramerization domain-containing 2. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.811 |
Kctd2 | Sumo2 | ENSRNOP00000059246 | ENSRNOP00000004867 | Potassium channel tetramerization domain-containing 2. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] | 0.625 |
Kctd2 | Sumo3 | ENSRNOP00000059246 | ENSRNOP00000001637 | Potassium channel tetramerization domain-containing 2. | Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such [...] | 0.629 |
Kctd2 | Sumo4 | ENSRNOP00000059246 | ENSRNOP00000044856 | Potassium channel tetramerization domain-containing 2. | Small ubiquitin-related modifier. | 0.623 |
Kctd2 | Uba2 | ENSRNOP00000059246 | ENSRNOP00000028672 | Potassium channel tetramerization domain-containing 2. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.814 |
LOC102553386 | D4A7L5_RAT | ENSRNOP00000075659 | ENSRNOP00000047101 | SUMO-conjugating enzyme UBC9-like. | Small ubiquitin-related modifier. | 0.653 |
LOC102553386 | Sae1 | ENSRNOP00000075659 | ENSRNOP00000020402 | SUMO-conjugating enzyme UBC9-like. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.911 |
LOC102553386 | Senp1 | ENSRNOP00000075659 | ENSRNOP00000031127 | SUMO-conjugating enzyme UBC9-like. | SUMO-specific peptidase 1. | 0.558 |
LOC102553386 | Sumo1 | ENSRNOP00000075659 | ENSRNOP00000022048 | SUMO-conjugating enzyme UBC9-like. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.927 |
LOC102553386 | Sumo2 | ENSRNOP00000075659 | ENSRNOP00000004867 | SUMO-conjugating enzyme UBC9-like. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] | 0.734 |
LOC102553386 | Sumo3 | ENSRNOP00000075659 | ENSRNOP00000001637 | SUMO-conjugating enzyme UBC9-like. | Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such [...] | 0.771 |