node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Btla | Cd80 | ENSRNOP00000050172 | ENSRNOP00000002089 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | CD80 antigen, isoform CRA_a. | 0.734 |
Btla | Ctla4 | ENSRNOP00000050172 | ENSRNOP00000073071 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a. | 0.778 |
Btla | Havcr2 | ENSRNOP00000050172 | ENSRNOP00000048351 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | Hepatitis A virus cellular receptor 2 homolog; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in [...] | 0.795 |
Btla | Icoslg | ENSRNOP00000050172 | ENSRNOP00000031382 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | Inducible T-cell co-stimulator ligand. | 0.633 |
Btla | Lag3 | ENSRNOP00000050172 | ENSRNOP00000036771 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | Secreted lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, act [...] | 0.875 |
Btla | Pdcd1 | ENSRNOP00000050172 | ENSRNOP00000067189 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | Programmed cell death 1. | 0.786 |
Btla | Pdcd1-2 | ENSRNOP00000050172 | ENSRNOP00000025743 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | Programmed cell death 1 (Predicted). | 0.814 |
Btla | Pdcd1lg2 | ENSRNOP00000050172 | ENSRNOP00000021615 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | Programmed cell death 1 ligand 2. | 0.705 |
Btla | Vtcn1 | ENSRNOP00000050172 | ENSRNOP00000020566 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | V-set domain-containing T-cell activation inhibitor 1; Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation (By similarity). | 0.811 |
Cd80 | Btla | ENSRNOP00000002089 | ENSRNOP00000050172 | CD80 antigen, isoform CRA_a. | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | 0.734 |
Cd80 | Ctla4 | ENSRNOP00000002089 | ENSRNOP00000073071 | CD80 antigen, isoform CRA_a. | Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a. | 0.999 |
Cd80 | Havcr2 | ENSRNOP00000002089 | ENSRNOP00000048351 | CD80 antigen, isoform CRA_a. | Hepatitis A virus cellular receptor 2 homolog; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in [...] | 0.940 |
Cd80 | Icoslg | ENSRNOP00000002089 | ENSRNOP00000031382 | CD80 antigen, isoform CRA_a. | Inducible T-cell co-stimulator ligand. | 0.841 |
Cd80 | Lag3 | ENSRNOP00000002089 | ENSRNOP00000036771 | CD80 antigen, isoform CRA_a. | Secreted lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, act [...] | 0.956 |
Cd80 | Pdcd1 | ENSRNOP00000002089 | ENSRNOP00000067189 | CD80 antigen, isoform CRA_a. | Programmed cell death 1. | 0.924 |
Cd80 | Pdcd1-2 | ENSRNOP00000002089 | ENSRNOP00000025743 | CD80 antigen, isoform CRA_a. | Programmed cell death 1 (Predicted). | 0.936 |
Cd80 | Pdcd1lg2 | ENSRNOP00000002089 | ENSRNOP00000021615 | CD80 antigen, isoform CRA_a. | Programmed cell death 1 ligand 2. | 0.867 |
Cd80 | Vtcn1 | ENSRNOP00000002089 | ENSRNOP00000020566 | CD80 antigen, isoform CRA_a. | V-set domain-containing T-cell activation inhibitor 1; Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation (By similarity). | 0.581 |
Ctla4 | Btla | ENSRNOP00000073071 | ENSRNOP00000050172 | Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a. | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | 0.778 |
Ctla4 | Cd80 | ENSRNOP00000073071 | ENSRNOP00000002089 | Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a. | CD80 antigen, isoform CRA_a. | 0.999 |