| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Brca1 | Ercc1 | ENSRNOP00000072366 | ENSRNOP00000024113 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | ERCC excision repair 1, endonuclease non-catalytic subunit. | 0.918 |
| Brca1 | Exo1 | ENSRNOP00000072366 | ENSRNOP00000073202 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Exonuclease 1. | 0.942 |
| Brca1 | Mlh1 | ENSRNOP00000072366 | ENSRNOP00000072285 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA mismatch repair protein Mlh1; Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...] | 0.969 |
| Brca1 | Mlh3 | ENSRNOP00000072366 | ENSRNOP00000038334 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | MutL homolog 3 (E. coli) (Predicted), isoform CRA_a. | 0.798 |
| Brca1 | Msh2 | ENSRNOP00000072366 | ENSRNOP00000021538 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a t [...] | 0.958 |
| Brca1 | Msh3 | ENSRNOP00000072366 | ENSRNOP00000018449 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.576 |
| Brca1 | Msh6 | ENSRNOP00000072366 | ENSRNOP00000021923 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.966 |
| Brca1 | Pms1 | ENSRNOP00000072366 | ENSRNOP00000047584 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | PMS1 homolog 1, mismatch repair system component. | 0.730 |
| Brca1 | Pms2 | ENSRNOP00000072366 | ENSRNOP00000069740 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | PMS1 homolog 2, mismatch repair system component. | 0.917 |
| Brca1 | Pold1 | ENSRNOP00000072366 | ENSRNOP00000026797 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] | 0.882 |
| Ercc1 | Brca1 | ENSRNOP00000024113 | ENSRNOP00000072366 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.918 |
| Ercc1 | Exo1 | ENSRNOP00000024113 | ENSRNOP00000073202 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Exonuclease 1. | 0.850 |
| Ercc1 | Mlh1 | ENSRNOP00000024113 | ENSRNOP00000072285 | ERCC excision repair 1, endonuclease non-catalytic subunit. | DNA mismatch repair protein Mlh1; Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...] | 0.907 |
| Ercc1 | Mlh3 | ENSRNOP00000024113 | ENSRNOP00000038334 | ERCC excision repair 1, endonuclease non-catalytic subunit. | MutL homolog 3 (E. coli) (Predicted), isoform CRA_a. | 0.828 |
| Ercc1 | Msh2 | ENSRNOP00000024113 | ENSRNOP00000021538 | ERCC excision repair 1, endonuclease non-catalytic subunit. | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a t [...] | 0.964 |
| Ercc1 | Msh3 | ENSRNOP00000024113 | ENSRNOP00000018449 | ERCC excision repair 1, endonuclease non-catalytic subunit. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.787 |
| Ercc1 | Msh6 | ENSRNOP00000024113 | ENSRNOP00000021923 | ERCC excision repair 1, endonuclease non-catalytic subunit. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.938 |
| Ercc1 | Pms1 | ENSRNOP00000024113 | ENSRNOP00000047584 | ERCC excision repair 1, endonuclease non-catalytic subunit. | PMS1 homolog 1, mismatch repair system component. | 0.750 |
| Ercc1 | Pms2 | ENSRNOP00000024113 | ENSRNOP00000069740 | ERCC excision repair 1, endonuclease non-catalytic subunit. | PMS1 homolog 2, mismatch repair system component. | 0.906 |
| Ercc1 | Pold1 | ENSRNOP00000024113 | ENSRNOP00000026797 | ERCC excision repair 1, endonuclease non-catalytic subunit. | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] | 0.845 |
STRING v12.5 is now available!
