Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PipProlactin-inducible protein homolog; Belongs to the PIP family. (146 aa)    
Predicted Functional Partners:
Azgp1
Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. Belongs to the MHC class I family.
   
 0.967
Grpca
Submandibular gland secretory Glx-rich protein CB; GRP proteins have a marked affinity for hydroxyapatite. They may play a role in the formation of the protective acquired pellicle at the saliva-tooth interface.
   
  
 0.742
Csap1
Common salivary protein 1.
   
  
 0.733
Bpifa2
BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
   
  
 0.715
Armh4
Armadillo-like helical domain-containing 4.
   
  
 0.650
P22k15
Cystatin-related protein 2; Belongs to the cystatin family.
   
  
 0.618
Tsacc
Similar to SSTK-interacting protein (Predicted), isoform CRA_a.
      
 0.591
Zp3
Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
  
  
 0.581
RGD1306750
Gliadoralin-A; May play a role in the formation of the protective mucosal protein pellicle involved in the reinforcement and protection of oral mucosal epithelial surface.
      
 0.573
Cst5
Cystatin 10 (Chondrocytes) (Predicted); Belongs to the cystatin family.
   
  
 0.562
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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