STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Npsr1Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. (371 aa)    
Predicted Functional Partners:
Nps
Neuropeptide S; May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.
     
 0.994
D3ZGS7_RAT
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 
 0.937
Fau
Ubiquitin-like protein FUBI.
   
 
 0.937
LOC687780
Ubiquitin-like protein fubi and ribosomal protein S30-like.
   
 
 0.937
LOC687780-2
FAU, ubiquitin like and ribosomal protein S30 fusion.
   
 
 0.937
Tufm
Elongation factor Tu, mitochondrial; Plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR- mediated type I interferon while promoting autophagy. Promotes the GTP- dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
  
 
 0.899
Mrpl17
39S ribosomal protein L17, mitochondrial; Belongs to the bacterial ribosomal protein bL17 family.
  
 
 0.893
Rpl23
60S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.
  
 
 0.886
Mrps16
Mitochondrial ribosomal protein S16.
   
 
 0.884
mrpl9
39S ribosomal protein L9, mitochondrial; Belongs to the bacterial ribosomal protein bL9 family.
   
 
 0.883
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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