Gucy2g protein (Rattus norvegicus) - STRING interaction network

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Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gch1	Gucy2g	ENSRNOP00000014821	ENSRNOP00000021744	GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family.	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.864
Gucy2g	Gch1	ENSRNOP00000021744	ENSRNOP00000014821	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family.	0.864
Gucy2g	Nppa	ENSRNOP00000021744	ENSRNOP00000011005	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).	0.906
Gucy2g	Nppb	ENSRNOP00000021744	ENSRNOP00000010778	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Brain natriuretic peptide 45; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). Belongs to the natriuretic peptide family.	0.916
Gucy2g	Pde1a	ENSRNOP00000021744	ENSRNOP00000072275	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.929
Gucy2g	Pde1c	ENSRNOP00000021744	ENSRNOP00000017531	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (B [...]	0.864
Gucy2g	Pde3a	ENSRNOP00000021744	ENSRNOP00000032282	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	cGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.	0.872
Gucy2g	Pde5a	ENSRNOP00000021744	ENSRNOP00000019637	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.	0.895
Gucy2g	Pde6a	ENSRNOP00000021744	ENSRNOP00000024171	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.879
Gucy2g	Pde6b	ENSRNOP00000021744	ENSRNOP00000000077	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.885
Gucy2g	Pde6c	ENSRNOP00000021744	ENSRNOP00000022317	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.874
Nppa	Gucy2g	ENSRNOP00000011005	ENSRNOP00000021744	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.906
Nppa	Nppb	ENSRNOP00000011005	ENSRNOP00000010778	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).	Brain natriuretic peptide 45; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). Belongs to the natriuretic peptide family.	0.994
Nppa	Pde5a	ENSRNOP00000011005	ENSRNOP00000019637	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).	cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.	0.637
Nppb	Gucy2g	ENSRNOP00000010778	ENSRNOP00000021744	Brain natriuretic peptide 45; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). Belongs to the natriuretic peptide family.	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.916
Nppb	Nppa	ENSRNOP00000010778	ENSRNOP00000011005	Brain natriuretic peptide 45; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). Belongs to the natriuretic peptide family.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).	0.994
Nppb	Pde5a	ENSRNOP00000010778	ENSRNOP00000019637	Brain natriuretic peptide 45; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). Belongs to the natriuretic peptide family.	cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.	0.463
Pde1a	Gucy2g	ENSRNOP00000072275	ENSRNOP00000021744	Phosphodiesterase.	Guanylate cyclase 2G; Binds to a yet not identified ligand; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.929
Pde1a	Pde1c	ENSRNOP00000072275	ENSRNOP00000017531	Phosphodiesterase.	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (B [...]	0.950
Pde1a	Pde3a	ENSRNOP00000072275	ENSRNOP00000032282	Phosphodiesterase.	cGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.	0.697

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