node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abca1 | Abcg1 | ENSRNOP00000024564 | ENSRNOP00000001533 | ATP-binding cassette, subfamily A (ABC1), member 1 | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | 0.448 |
Abca1 | Apoa1 | ENSRNOP00000024564 | ENSRNOP00000065206 | ATP-binding cassette, subfamily A (ABC1), member 1 | Apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family | 0.999 |
Abca1 | Apoa2 | ENSRNOP00000024564 | ENSRNOP00000004662 | ATP-binding cassette, subfamily A (ABC1), member 1 | Apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family | 0.731 |
Abca1 | Apob | ENSRNOP00000024564 | ENSRNOP00000039779 | ATP-binding cassette, subfamily A (ABC1), member 1 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor | 0.824 |
Abca1 | Apoe | ENSRNOP00000024564 | ENSRNOP00000050968 | ATP-binding cassette, subfamily A (ABC1), member 1 | Apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | 0.944 |
Abca1 | Clu | ENSRNOP00000024564 | ENSRNOP00000022095 | ATP-binding cassette, subfamily A (ABC1), member 1 | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or prot [...] | 0.491 |
Abca1 | Lcat | ENSRNOP00000024564 | ENSRNOP00000026583 | ATP-binding cassette, subfamily A (ABC1), member 1 | Lecithin-cholesterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and influences cerebral spinal fluid [...] | 0.794 |
Abca1 | Pltp | ENSRNOP00000024564 | ENSRNOP00000022594 | ATP-binding cassette, subfamily A (ABC1), member 1 | Phospholipid transfer protein | 0.856 |
Abca1 | Scarb1 | ENSRNOP00000024564 | ENSRNOP00000060874 | ATP-binding cassette, subfamily A (ABC1), member 1 | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity | 0.934 |
Abcg1 | Abca1 | ENSRNOP00000001533 | ENSRNOP00000024564 | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | ATP-binding cassette, subfamily A (ABC1), member 1 | 0.448 |
Abcg1 | Apoa1 | ENSRNOP00000001533 | ENSRNOP00000065206 | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | Apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family | 0.925 |
Abcg1 | Apoa2 | ENSRNOP00000001533 | ENSRNOP00000004662 | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | Apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family | 0.574 |
Abcg1 | Apob | ENSRNOP00000001533 | ENSRNOP00000039779 | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor | 0.723 |
Abcg1 | Apoe | ENSRNOP00000001533 | ENSRNOP00000050968 | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | Apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | 0.872 |
Abcg1 | Lcat | ENSRNOP00000001533 | ENSRNOP00000026583 | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | Lecithin-cholesterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and influences cerebral spinal fluid [...] | 0.721 |
Abcg1 | Pltp | ENSRNOP00000001533 | ENSRNOP00000022594 | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | Phospholipid transfer protein | 0.712 |
Abcg1 | Scarb1 | ENSRNOP00000001533 | ENSRNOP00000060874 | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity | 0.870 |
Apoa1 | Abca1 | ENSRNOP00000065206 | ENSRNOP00000024564 | Apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family | ATP-binding cassette, subfamily A (ABC1), member 1 | 0.999 |
Apoa1 | Abcg1 | ENSRNOP00000065206 | ENSRNOP00000001533 | Apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family | Atp-binding cassette, sub-family g (white), member 1, isoform cra_a; ATP-binding cassette, subfamily G (WHITE), member 1 | 0.925 |
Apoa1 | Apoa2 | ENSRNOP00000065206 | ENSRNOP00000004662 | Apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family | Apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family | 0.999 |