Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Nhlrc2NHL repeat containing 2 (Predicted). (725 aa)    
Predicted Functional Partners:
Tm2d3
TM2 domain-containing 3.
      
 0.806
Tm2d2
TM2 domain-containing protein 2.
      
 0.801
Sh3glb1
Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...]
    
  0.773
Tm2d1
TM2 domain containing 1 (Predicted), isoform CRA_a.
   
  
 0.740
Ccdc186
Coiled-coil domain-containing 186.
   
  
 0.700
Plekhs1
Similar to RIKEN cDNA 9930023K05 (Predicted).
      
 0.670
Vwa2
Von Willebrand factor A domain-containing 2.
    
 0.656
Nprl2
Tumor suppressor candidate 4, isoform CRA_a.
   
 
 0.607
Lamtor2
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.
      
 0.602
Zdhhc6
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
   
  
 0.595
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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