node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abcd1 | Abcd2 | ENSRNOP00000070359 | ENSRNOP00000021064 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | ATP-binding cassette sub-family D member 2; Probable transporter. | 0.923 |
Abcd1 | Abcd3 | ENSRNOP00000070359 | ENSRNOP00000016739 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched- chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide- binding fold acts as an ATP-binding subunit with ATPase activity. | 0.963 |
Abcd1 | Atad1 | ENSRNOP00000070359 | ENSRNOP00000072875 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent. | 0.729 |
Abcd1 | LOC100911356 | ENSRNOP00000070359 | ENSRNOP00000032453 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. | 0.873 |
Abcd1 | Pex11b | ENSRNOP00000070359 | ENSRNOP00000028811 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | Peroxisomal biogenesis factor 11b, isoform CRA_b. | 0.769 |
Abcd1 | Pex13 | ENSRNOP00000070359 | ENSRNOP00000068751 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | Peroxisomal biogenesis factor 13 (Predicted). | 0.846 |
Abcd1 | Pex16 | ENSRNOP00000070359 | ENSRNOP00000070009 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | Peroxisomal membrane protein PEX16. | 0.816 |
Abcd1 | Pxmp2 | ENSRNOP00000070359 | ENSRNOP00000053518 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane. | 0.777 |
Abcd1 | Pxmp4 | ENSRNOP00000070359 | ENSRNOP00000022914 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | Peroxisomal membrane protein 4. | 0.766 |
Abcd1 | Tmem135 | ENSRNOP00000070359 | ENSRNOP00000022578 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission (By similarity). May act as a regulator of mitochondrial fission that promotes DNM1L- dependent fission through activation of DNM1L (By similarity). May be involved in peroxisome organization. Belongs to the TMEM135 family. | 0.474 |
Abcd2 | Abcd1 | ENSRNOP00000021064 | ENSRNOP00000070359 | ATP-binding cassette sub-family D member 2; Probable transporter. | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | 0.923 |
Abcd2 | Abcd3 | ENSRNOP00000021064 | ENSRNOP00000016739 | ATP-binding cassette sub-family D member 2; Probable transporter. | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched- chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide- binding fold acts as an ATP-binding subunit with ATPase activity. | 0.935 |
Abcd2 | Atad1 | ENSRNOP00000021064 | ENSRNOP00000072875 | ATP-binding cassette sub-family D member 2; Probable transporter. | ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent. | 0.712 |
Abcd2 | LOC100911356 | ENSRNOP00000021064 | ENSRNOP00000032453 | ATP-binding cassette sub-family D member 2; Probable transporter. | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. | 0.835 |
Abcd2 | Pex11b | ENSRNOP00000021064 | ENSRNOP00000028811 | ATP-binding cassette sub-family D member 2; Probable transporter. | Peroxisomal biogenesis factor 11b, isoform CRA_b. | 0.697 |
Abcd2 | Pex13 | ENSRNOP00000021064 | ENSRNOP00000068751 | ATP-binding cassette sub-family D member 2; Probable transporter. | Peroxisomal biogenesis factor 13 (Predicted). | 0.822 |
Abcd2 | Pex16 | ENSRNOP00000021064 | ENSRNOP00000070009 | ATP-binding cassette sub-family D member 2; Probable transporter. | Peroxisomal membrane protein PEX16. | 0.789 |
Abcd2 | Pxmp2 | ENSRNOP00000021064 | ENSRNOP00000053518 | ATP-binding cassette sub-family D member 2; Probable transporter. | Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane. | 0.697 |
Abcd2 | Pxmp4 | ENSRNOP00000021064 | ENSRNOP00000022914 | ATP-binding cassette sub-family D member 2; Probable transporter. | Peroxisomal membrane protein 4. | 0.766 |
Abcd2 | Tmem135 | ENSRNOP00000021064 | ENSRNOP00000022578 | ATP-binding cassette sub-family D member 2; Probable transporter. | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission (By similarity). May act as a regulator of mitochondrial fission that promotes DNM1L- dependent fission through activation of DNM1L (By similarity). May be involved in peroxisome organization. Belongs to the TMEM135 family. | 0.427 |