node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akr1d1 | Cyp11b2 | ENSRNOP00000017675 | ENSRNOP00000049722 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | 0.926 |
Akr1d1 | Cyp21a1 | ENSRNOP00000017675 | ENSRNOP00000037516 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. | 0.908 |
Akr1d1 | Hsd11b2 | ENSRNOP00000017675 | ENSRNOP00000023130 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.943 |
Akr1d1 | Hsd3b2 | ENSRNOP00000017675 | ENSRNOP00000026306 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.933 |
Akr1d1 | Hsd3b5 | ENSRNOP00000017675 | ENSRNOP00000072555 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase; Belongs to the 3-beta-HSD family. | 0.934 |
Cyp11b2 | Akr1d1 | ENSRNOP00000049722 | ENSRNOP00000017675 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). | 0.926 |
Cyp11b2 | Cyp21a1 | ENSRNOP00000049722 | ENSRNOP00000037516 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. | 0.962 |
Cyp11b2 | Hsd11b1 | ENSRNOP00000049722 | ENSRNOP00000050581 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | Corticosteroid 11-beta-dehydrogenase isozyme 1. | 0.614 |
Cyp11b2 | Hsd11b2 | ENSRNOP00000049722 | ENSRNOP00000023130 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.970 |
Cyp11b2 | Hsd3b2 | ENSRNOP00000049722 | ENSRNOP00000026306 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.981 |
Cyp11b2 | Hsd3b5 | ENSRNOP00000049722 | ENSRNOP00000072555 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase; Belongs to the 3-beta-HSD family. | 0.958 |
Cyp11b2 | Nr3c1 | ENSRNOP00000049722 | ENSRNOP00000044335 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | Glucocorticoid receptor. | 0.493 |
Cyp11b2 | Nr3c1-2 | ENSRNOP00000049722 | ENSRNOP00000019409 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.493 |
Cyp11b2 | Nr3c2 | ENSRNOP00000049722 | ENSRNOP00000045942 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels; Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.799 |
Cyp11b2 | Scnn1g | ENSRNOP00000049722 | ENSRNOP00000024057 | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | Amiloride-sensitive sodium channel subunit gamma; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. | 0.614 |
Cyp21a1 | Akr1d1 | ENSRNOP00000037516 | ENSRNOP00000017675 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). | 0.908 |
Cyp21a1 | Cyp11b2 | ENSRNOP00000037516 | ENSRNOP00000049722 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | 0.962 |
Cyp21a1 | Hsd11b1 | ENSRNOP00000037516 | ENSRNOP00000050581 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. | Corticosteroid 11-beta-dehydrogenase isozyme 1. | 0.467 |
Cyp21a1 | Hsd11b2 | ENSRNOP00000037516 | ENSRNOP00000023130 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.954 |
Cyp21a1 | Hsd3b2 | ENSRNOP00000037516 | ENSRNOP00000026306 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.979 |