node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd44 | Cldn7 | ENSRNOP00000009000 | ENSRNOP00000069209 | CD44 antigen. | Claudin-7; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family. | 0.809 |
Cd44 | Epcam | ENSRNOP00000009000 | ENSRNOP00000021135 | CD44 antigen. | Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family. | 0.934 |
Cd44 | Tjp1 | ENSRNOP00000009000 | ENSRNOP00000072324 | CD44 antigen. | Tight junction protein ZO-1; TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role [...] | 0.408 |
Cd44 | Tspan8 | ENSRNOP00000009000 | ENSRNOP00000005909 | CD44 antigen. | Tetraspanin. | 0.703 |
Cldn23 | Cldn4 | ENSRNOP00000015175 | ENSRNOP00000002003 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.825 |
Cldn23 | Cldn6 | ENSRNOP00000015175 | ENSRNOP00000004845 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.710 |
Cldn23 | Cldn7 | ENSRNOP00000015175 | ENSRNOP00000069209 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-7; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family. | 0.776 |
Cldn23 | Ocln | ENSRNOP00000015175 | ENSRNOP00000024674 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells. Belongs to the ELL/occludin family. | 0.760 |
Cldn23 | Tjp1 | ENSRNOP00000015175 | ENSRNOP00000072324 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein ZO-1; TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role [...] | 0.727 |
Cldn23 | Tjp3 | ENSRNOP00000015175 | ENSRNOP00000027847 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein 3 (Predicted), isoform CRA_b; Belongs to the MAGUK family. | 0.742 |
Cldn4 | Cldn23 | ENSRNOP00000002003 | ENSRNOP00000015175 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.825 |
Cldn4 | Cldn6 | ENSRNOP00000002003 | ENSRNOP00000004845 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.718 |
Cldn4 | Cldn7 | ENSRNOP00000002003 | ENSRNOP00000069209 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-7; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family. | 0.832 |
Cldn4 | Epcam | ENSRNOP00000002003 | ENSRNOP00000021135 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family. | 0.698 |
Cldn4 | Ocln | ENSRNOP00000002003 | ENSRNOP00000024674 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells. Belongs to the ELL/occludin family. | 0.984 |
Cldn4 | Tacstd2 | ENSRNOP00000002003 | ENSRNOP00000010156 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tumor-associated calcium signal transducer 2; May function as a growth factor receptor; Belongs to the EPCAM family. | 0.430 |
Cldn4 | Tjp1 | ENSRNOP00000002003 | ENSRNOP00000072324 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein ZO-1; TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role [...] | 0.992 |
Cldn4 | Tjp3 | ENSRNOP00000002003 | ENSRNOP00000027847 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein 3 (Predicted), isoform CRA_b; Belongs to the MAGUK family. | 0.913 |
Cldn6 | Cldn23 | ENSRNOP00000004845 | ENSRNOP00000015175 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.710 |
Cldn6 | Cldn4 | ENSRNOP00000004845 | ENSRNOP00000002003 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.718 |