node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ddx51 | Pnpt1 | ENSRNOP00000073152 | ENSRNOP00000004919 | DEAD-box helicase 51; Belongs to the DEAD box helicase family. | Polyribonucleotide nucleotidyltransferase 1. | 0.505 |
Ddx51 | Rexo1 | ENSRNOP00000073152 | ENSRNOP00000024080 | DEAD-box helicase 51; Belongs to the DEAD box helicase family. | RNA exonuclease 1 homolog. | 0.693 |
Ddx51 | Wdr61 | ENSRNOP00000073152 | ENSRNOP00000017239 | DEAD-box helicase 51; Belongs to the DEAD box helicase family. | WD repeat-containing protein 61, N-terminally processed; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for tran [...] | 0.732 |
Dus3l | Rexo1 | ENSRNOP00000066698 | ENSRNOP00000024080 | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus3 subfamily. | RNA exonuclease 1 homolog. | 0.684 |
Dus3l | Scamp4 | ENSRNOP00000066698 | ENSRNOP00000024980 | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus3 subfamily. | Secretory carrier-associated membrane protein 4; Probably involved in membrane protein trafficking. Belongs to the SCAMP family. | 0.700 |
Pan3 | Rexo1 | ENSRNOP00000040388 | ENSRNOP00000024080 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | RNA exonuclease 1 homolog. | 0.615 |
Pan3 | Rexo1l1-ps1 | ENSRNOP00000040388 | ENSRNOP00000069746 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | REX1, RNA exonuclease 1 homolog-like 1, pseudogene 1. | 0.604 |
Pan3 | Rexo5 | ENSRNOP00000040388 | ENSRNOP00000073863 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | RNA exonuclease 5. | 0.604 |
Pcna | Pnpt1 | ENSRNOP00000028887 | ENSRNOP00000004919 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | Polyribonucleotide nucleotidyltransferase 1. | 0.449 |
Pcna | Rexo1 | ENSRNOP00000028887 | ENSRNOP00000024080 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | RNA exonuclease 1 homolog. | 0.686 |
Pcna | Rexo1l1-ps1 | ENSRNOP00000028887 | ENSRNOP00000069746 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | REX1, RNA exonuclease 1 homolog-like 1, pseudogene 1. | 0.686 |
Pcna | Rexo5 | ENSRNOP00000028887 | ENSRNOP00000073863 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | RNA exonuclease 5. | 0.686 |
Pnpt1 | Ddx51 | ENSRNOP00000004919 | ENSRNOP00000073152 | Polyribonucleotide nucleotidyltransferase 1. | DEAD-box helicase 51; Belongs to the DEAD box helicase family. | 0.505 |
Pnpt1 | Pcna | ENSRNOP00000004919 | ENSRNOP00000028887 | Polyribonucleotide nucleotidyltransferase 1. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.449 |
Pnpt1 | Rexo1 | ENSRNOP00000004919 | ENSRNOP00000024080 | Polyribonucleotide nucleotidyltransferase 1. | RNA exonuclease 1 homolog. | 0.660 |
Pnpt1 | Rexo1l1-ps1 | ENSRNOP00000004919 | ENSRNOP00000069746 | Polyribonucleotide nucleotidyltransferase 1. | REX1, RNA exonuclease 1 homolog-like 1, pseudogene 1. | 0.443 |
Pnpt1 | Rexo2 | ENSRNOP00000004919 | ENSRNOP00000071290 | Polyribonucleotide nucleotidyltransferase 1. | Oligoribonuclease, mitochondrial; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role for cellular nucleotide recycling (By similarity); Belongs to the oligoribonuclease family. | 0.538 |
Pnpt1 | Rexo5 | ENSRNOP00000004919 | ENSRNOP00000073863 | Polyribonucleotide nucleotidyltransferase 1. | RNA exonuclease 5. | 0.443 |
Rexo1 | Ddx51 | ENSRNOP00000024080 | ENSRNOP00000073152 | RNA exonuclease 1 homolog. | DEAD-box helicase 51; Belongs to the DEAD box helicase family. | 0.693 |
Rexo1 | Dus3l | ENSRNOP00000024080 | ENSRNOP00000066698 | RNA exonuclease 1 homolog. | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus3 subfamily. | 0.684 |