node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abcb10 | Alas2 | ENSRNOP00000024232 | ENSRNOP00000000180 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 0.672 |
Abcb10 | Fech | ENSRNOP00000024232 | ENSRNOP00000024328 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.982 |
Abcb10 | Flvcr1 | ENSRNOP00000024232 | ENSRNOP00000066732 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | Feline leukemia virus subgroup C cellular receptor 1. | 0.674 |
Abcb10 | Ppox | ENSRNOP00000024232 | ENSRNOP00000004896 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.673 |
Abcb10 | Slc25a28 | ENSRNOP00000024232 | ENSRNOP00000022633 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | Solute carrier family 25 member 28; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.755 |
Abcb10 | Slc25a37 | ENSRNOP00000024232 | ENSRNOP00000021636 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | Mitoferrin-1; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.914 |
Abcb10 | Slc25a38 | ENSRNOP00000024232 | ENSRNOP00000025142 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. | 0.617 |
Abcb10 | Steap3 | ENSRNOP00000024232 | ENSRNOP00000064137 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin- dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. | 0.695 |
Abcb10 | Tmem14c | ENSRNOP00000024232 | ENSRNOP00000020737 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | Transmembrane protein 14C; Required for normal heme biosynthesis; Belongs to the TMEM14 family. | 0.684 |
Abcb10 | Uros | ENSRNOP00000024232 | ENSRNOP00000024278 | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | Uroporphyrinogen III synthase. | 0.617 |
Alas2 | Abcb10 | ENSRNOP00000000180 | ENSRNOP00000024232 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | 0.672 |
Alas2 | Fech | ENSRNOP00000000180 | ENSRNOP00000024328 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.871 |
Alas2 | Flvcr1 | ENSRNOP00000000180 | ENSRNOP00000066732 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Feline leukemia virus subgroup C cellular receptor 1. | 0.525 |
Alas2 | Ppox | ENSRNOP00000000180 | ENSRNOP00000004896 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.754 |
Alas2 | Slc25a28 | ENSRNOP00000000180 | ENSRNOP00000022633 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Solute carrier family 25 member 28; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.431 |
Alas2 | Slc25a37 | ENSRNOP00000000180 | ENSRNOP00000021636 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Mitoferrin-1; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.704 |
Alas2 | Slc25a38 | ENSRNOP00000000180 | ENSRNOP00000025142 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. | 0.743 |
Alas2 | Steap3 | ENSRNOP00000000180 | ENSRNOP00000064137 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin- dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. | 0.445 |
Alas2 | Uros | ENSRNOP00000000180 | ENSRNOP00000024278 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Uroporphyrinogen III synthase. | 0.745 |
Fech | Abcb10 | ENSRNOP00000024328 | ENSRNOP00000024232 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | ATP-binding cassette, sub-family B (MDR/TAP), member 10. | 0.982 |