| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bag1 | Bag2 | ENSRNOP00000011455 | ENSRNOP00000016948 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | BAG cochaperone 2. | 0.992 |
| Bag1 | Hspa1b | ENSRNOP00000011455 | ENSRNOP00000075599 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Heat shock protein family A (Hsp70) member 1B. | 0.839 |
| Bag1 | Hspa4 | ENSRNOP00000011455 | ENSRNOP00000023628 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.995 |
| Bag1 | Hspa4l | ENSRNOP00000011455 | ENSRNOP00000015474 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Heat shock 70 kDa protein 4L. | 0.932 |
| Bag1 | Hspbp1 | ENSRNOP00000011455 | ENSRNOP00000024251 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). | 0.949 |
| Bag1 | Hsph1 | ENSRNOP00000011455 | ENSRNOP00000001201 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.971 |
| Bag1 | Stub1 | ENSRNOP00000011455 | ENSRNOP00000026921 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | STIP1 homology and U-Box containing protein 1, isoform CRA_b. | 0.974 |
| Bag2 | Bag1 | ENSRNOP00000016948 | ENSRNOP00000011455 | BAG cochaperone 2. | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | 0.992 |
| Bag2 | Hspa1b | ENSRNOP00000016948 | ENSRNOP00000075599 | BAG cochaperone 2. | Heat shock protein family A (Hsp70) member 1B. | 0.761 |
| Bag2 | Hspa4 | ENSRNOP00000016948 | ENSRNOP00000023628 | BAG cochaperone 2. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.971 |
| Bag2 | Hspa4l | ENSRNOP00000016948 | ENSRNOP00000015474 | BAG cochaperone 2. | Heat shock 70 kDa protein 4L. | 0.945 |
| Bag2 | Hspbp1 | ENSRNOP00000016948 | ENSRNOP00000024251 | BAG cochaperone 2. | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). | 0.951 |
| Bag2 | Hsph1 | ENSRNOP00000016948 | ENSRNOP00000001201 | BAG cochaperone 2. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.972 |
| Bag2 | Stub1 | ENSRNOP00000016948 | ENSRNOP00000026921 | BAG cochaperone 2. | STIP1 homology and U-Box containing protein 1, isoform CRA_b. | 0.992 |
| Hsf1 | Hspa1b | ENSRNOP00000047030 | ENSRNOP00000075599 | Heat shock transcription factor 1. | Heat shock protein family A (Hsp70) member 1B. | 0.879 |
| Hsf1 | Hspa4 | ENSRNOP00000047030 | ENSRNOP00000023628 | Heat shock transcription factor 1. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.951 |
| Hsf1 | Hspbp1 | ENSRNOP00000047030 | ENSRNOP00000024251 | Heat shock transcription factor 1. | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). | 0.946 |
| Hsf1 | Hsph1 | ENSRNOP00000047030 | ENSRNOP00000001201 | Heat shock transcription factor 1. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.566 |
| Hsf1 | Stub1 | ENSRNOP00000047030 | ENSRNOP00000026921 | Heat shock transcription factor 1. | STIP1 homology and U-Box containing protein 1, isoform CRA_b. | 0.841 |
| Hspa1b | Bag1 | ENSRNOP00000075599 | ENSRNOP00000011455 | Heat shock protein family A (Hsp70) member 1B. | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | 0.839 |
